Neutral Core Human Milk Oligosaccharides Anti-Ageing
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Solution Overview
Problem
There is a need for natural ingredients that can increase collagen production to counteract skin aging and its visible signs, such as fine lines, wrinkles, and sagging.
Innovation Solution
The use of neutral core human milk oligosaccharides, specifically lacto-N-(neo)tetraoses, which are composed of galactose, N-acetylglucosamine, and glucose, to stimulate collagen synthesis in human dermal fibroblasts.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional anti-ageing treatments are used, then skin aging signs are addressed, but natural ingredients that increase collagen production are needed
Solution Approach 1:
The patent changes the chemical parameter by introducing specific human milk oligosaccharides (HMOs) with defined structures (lacto-N-tetraose, lacto-N-neotetraose, and related compounds) to stimulate collagen production. These oligosaccharides contain specific monosaccharide units (galactose, N-acetylglucosamine, glucose) in particular configurations that trigger fibroblast activity and increase type I collagen synthesis, directly addressing the need for natural ingredients that boost collagen production.
2Object-affected harmful factors
If collagen production is increased to counteract skin aging, then visible signs of aging are reduced, but the mechanism must be natural and effective
Solution Approach 1:
The patent employs human milk oligosaccharides that naturally occur in breast milk to stimulate fibroblasts to produce collagen autonomously. These oligosaccharides act as signaling molecules that trigger the fibroblasts' intrinsic collagen synthesis pathways without requiring external intervention or complex treatment protocols. The natural origin and self-stimulating mechanism ensure both natural composition and reliable effectiveness in reducing visible aging signs.
Solution Approach 2:
The human milk oligosaccharides serve as intermediary substances that mediate between the natural environment and the fibroblast cells. These oligosaccharides (particularly lacto-N-tetraose and lacto-N-neotetraose structures) act as signaling intermediaries that bind to fibroblast receptors and initiate intracellular pathways leading to increased type I collagen production, thereby translating a natural ingredient into a reliable anti-ageing effect.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These oligosaccharides significantly increase type I collagen production in human dermal fibroblasts, thereby maintaining skin homeostasis and reducing the visible signs of skin aging.
Implementation Method 1
certain human milk oligosaccharides namely the neutral core human milk oligosaccharides composed of galactose, N-acetylglucosamine, and glucose monosaccharide such as Lacto-N-Tetraose (LNT) or Lacto-N-Neotetraose (LNnT) are able to significantly increase collagen synthesis in human dermal fibroblasts
Data Source
AI summary
The present invention relates to the use of neutral core human milk oligosaccharides such as in particular lacto-N-(neo)tetraoses as anti-ageing active ingredient as well as the use thereof in topical anti-ageing compositions.