NHDC and Peppermint Oil Animal Feed Supplement for Campylobacter Reduction
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Solution Overview
Problem
Current methods to reduce Campylobacter spp. carriage in poultry and swine, particularly Campylobacter jejuni, are inadequate in vivo, despite showing positive effects in vitro, and there is a need for antibiotic alternatives to mitigate the risk of Campylobacteriosis in humans.
Innovation Solution
A food supplement comprising neohesperidin dihydrochalcone (NHDC) and peppermint oil (PMO) is formulated in specific ratios and administered in animal feeds to significantly reduce Campylobacter jejuni carriage, achieving a synergistic effect in both in vitro and in vivo trials.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If plant-based compounds like carvacrol, curcumin, or peppermint oil are used to reduce Campylobacter jejuni carriage, then in vitro effects show positive reduction of cell invasion and asymptomatic carriage, but in vivo effects on asymptomatic carriage have not been demonstrated
Solution Approach 1:
The patent combines neohesperidin dihydrochalcone (NHDC) and peppermint oil (PMO) into a single food supplement formulation. This merging of two active plant-based compounds creates a synergistic effect that reliably reduces Campylobacter jejuni carriage in vivo, overcoming the limitation of individual compounds tested separately in vitro.
Solution Approach 2:
The invention uses a composite formulation consisting of NHDC and PMO in specific ratios (0.5 to 1 weight ratio). This composite material approach allows the two compounds to work together synergistically, achieving reliable in vivo reduction of Campylobacter carriage that neither compound achieves alone, while maintaining a manageable formulation complexity.
2Reliability
If antibiotics are used to reduce asymptomatic carriage of Campylobacter spp., then the carriage is reduced, but antibiotic resistance develops
Solution Approach 1:
The patent converts the harmful effect of antibiotic overuse (which leads to resistance) into a beneficial alternative by using plant-based compounds NHDC and PMO. These compounds effectively reduce Campylobacter carriage without the harmful side effect of inducing antibiotic resistance, thus converting the problem of antibiotic resistance into an opportunity for safer alternatives.
Solution Approach 2:
The invention employs short-acting plant-based compounds NHDC and PMO that provide effective Campylobacter reduction during the treatment period but do not persist to cause long-term resistance issues. This approach replaces long-lasting antibiotics with shorter-acting natural compounds that achieve the same carriage reduction goal without the resistance problem.
3Reliability
If higher doses of plant-based compounds are used to achieve in vivo reduction, then Campylobacter carriage decreases, but the complexity of feed formulation and administration increases
Solution Approach 1:
The patent optimizes the concentration parameters of NHDC and PMO in the feed, using specific dosage ranges (NHDC: 5-50 ppm, PMO: 10-100 ppm) to achieve effective Campylobacter reduction. By carefully adjusting these concentration parameters, the formulation achieves reliable in vivo effects while maintaining manageable feed formulation complexity and avoiding excessive dosing.
Data Source
AI summary
The invention relates to a food product for animals which can be used as a prophylactic measure to reduce the number of Campylobacter jejuni in hosts like poultry or swine.More specifically the invention is a food supplement comprising neohesperidin dihydrochalcone (NHDC) and peppermint oil (PMO).The invention also pertains to a feed comprising such a food supplement as well as to its use to reduce campylobacter carriage by poultry or swine and to a method of reducing the risk of Campylobacter spp. infection in humans.