Niacinamide and Picolinamide Composition for Antimicrobial Peptide Induction
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Solution Overview
Problem
Current antimicrobial compositions for skin hygiene often rely on post-infection treatment or minimal antimicrobial residue, and there is a need for a long-lasting, leave-on application that enhances innate immunity by inducing the secretion of antimicrobial peptides (AMPs).
Innovation Solution
A topical composition comprising Niacinamide and picolinamide in a specific molar ratio (1:20 to 20:1) is applied to the skin, which synergistically induces the secretion of AMPs, providing long-lasting antimicrobial benefits and improved skin hygiene.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If niacinamide alone is used to induce AMP generation, then antimicrobial benefit is provided, but the antimicrobial efficacy is not sufficient for long-lasting protection
Solution Approach 1:
The patent combines niacinamide and picolinamide in a specific molar ratio (1:20 to 20:1) to create a synergistic effect. This merging of two compounds enhances the induction of antimicrobial peptides (AMPs) in keratinocytes, providing both reliable antimicrobial efficacy and prolonged protection duration that neither compound achieves alone.
Solution Approach 2:
The patent optimizes the molar ratio parameter of niacinamide to picolinamide (1:20 to 20:1) to achieve maximum synergistic effect. By adjusting this critical parameter, the composition achieves enhanced AMP generation and prolonged antimicrobial protection, resolving the contradiction between efficacy and duration.
2Duration of action of moving object
If a composition provides long-lasting antimicrobial protection through AMP induction, then the duration of action is improved, but the complexity of the composition increases
Solution Approach 1:
The patent merges two relatively simple compounds (niacinamide and picolinamide) in a specific ratio to achieve complex biological effects. This approach provides long-lasting protection through AMP induction while maintaining formulation simplicity, as both compounds are well-established skincare ingredients with known safety profiles.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively enhances AMP generation, offering prolonged antimicrobial protection up to 24 hours by activating keratinocytes, thereby boosting the skin's natural defense against germs and infections.
Implementation Method 1
Niacinamide is known in the art for inducing AMP generation on the skin thereby providing antimicrobial benefit. The present inventors have been working to provide hygiene benefits to consumers through the route of enhancing the AMP levels in the skin.
Implementation Method 2
The present inventors while working extensively on this have surprisingly found that a composition comprising Niacinamide and picolinamide in a particular ratio provides significantly better antimicrobial benefit by inducing AMP when compared to Niacinamide alone
Data Source
AI summary
The present invention relates to a topical composition and more particularly a topical composition for antimicrobial benefit. According to the present invention there is provided a topical composition comprising Niacinamide and picolinamide wherein the molar ratio of Niacinamide to picolinamide is from I:20 to 20:I.