Nicotine Delivery Product via Reduced Water Mixing

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Solution Overview

Problem

Existing nicotine delivery products, such as those using cation exchange resins and polyols, require high water content to form a slurry, which is time-consuming, energy-intensive, and reduces production capacity, while also having limited nicotine release rates.

Innovation Solution

A method involving mixing nicotine with a cation exchange resin and a polyol in a mixture with a reduced water content (26-45% by weight) to form a soft paste, followed by water removal, which achieves a nicotine release rate of at least 70% over a 10-minute period without the need for a slurry formation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If high water content is used to form a slurry mixture, then the mixing process achieves adequate homogeneity, but the processing time and energy consumption increase significantly

Engineering Contradiction:
Improvehomogeneity of mixtureVSAvoidprocessing time
Core Design Contradiction:
Stability of the object's compositionVSLoss of time

Solution Approach 1:

The patent changes the water content parameter from high (traditional slurry formation) to reduced (26-45% by weight), transforming the mixture from a slurry to a soft paste. This parameter change maintains adequate homogeneity while significantly reducing processing time and energy consumption during water removal.

Inventive Principle:
Principle #35Parameter changes

2Stability of the object's composition

If high water content is used to form a slurry mixture, then the mixing process achieves adequate homogeneity, but the energy consumption increases significantly

Engineering Contradiction:
Improvehomogeneity of mixtureVSAvoidenergy consumption
Core Design Contradiction:
Stability of the object's compositionVSUse of energy by moving object

Solution Approach 1:

The patent changes the water content parameter from high (traditional slurry formation) to reduced (26-45% by weight), transforming the mixture from a slurry to a soft paste. This parameter change maintains adequate homogeneity while significantly reducing energy consumption during the water removal process.

Inventive Principle:
Principle #35Parameter changes

3Stability of the object's composition

If high water content is used to form a slurry mixture, then the mixing process achieves adequate homogeneity, but the production capacity decreases

Engineering Contradiction:
Improvehomogeneity of mixtureVSAvoidproduction capacity
Core Design Contradiction:
Stability of the object's compositionVSProductivity

Solution Approach 1:

The patent changes the water content parameter from high (traditional slurry formation) to reduced (26-45% by weight), transforming the mixture from a slurry to a soft paste. This parameter change maintains adequate homogeneity while significantly reducing processing time, thereby increasing production capacity.

Inventive Principle:
Principle #35Parameter changes

4Stability of the object's composition

If traditional slurry formation is used, then adequate mixing is achieved, but the nicotine release rate is limited

Engineering Contradiction:
Improvemixing qualityVSAvoidnicotine release rate
Core Design Contradiction:
Stability of the object's compositionVSReliability

Solution Approach 1:

The patent changes the water content parameter from high (traditional slurry formation) to reduced (26-45% by weight), transforming the mixture from a slurry to a soft paste. This parameter change maintains adequate mixing quality while achieving superior nicotine release rates of at least 70% over 10 minutes.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method results in a nicotine delivery product with comparable nicotine loading capacity and release rates to existing products, while improving handling and reducing dust release, and significantly reducing processing time and energy consumption.

Implementation Method 1

mixing an aqueous solution of nicotine with a cation exchange resin forming a nicotine/cation exchange resin complex

Methodology Applied
Scientific EffectIon exchange: Ion Exchange

Implementation Method 2

removing water from the mixture to produce said nicotine delivery product

Methodology Applied
Scientific EffectEvaporation: Evaporation

Data Source

PatentUS8986668B2Method of manufacturing a nicotine delivery product
Publication Date: 2015.03.24 FERTIN PHARMA AS

AI summary

A method of manufacturing a nicotine delivery product comprising nicotine and a cation exchange resin. More precisely, to a method for preparing a nicotine delivery product said method comprising (a) mixing nicotine, a cation exchange resin, an organic polyol and water to form a mixture wherein the total amount of water is from 26 to 45% by weight of the total mixture, and (b) removing water from the mixture to produce said nicotine delivery product.