Nicotine Delivery Product Using Polyol Resin Complex
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Solution Overview
Problem
Existing nicotine delivery products face challenges in achieving a high nicotine release rate over a 10-minute period, with many having shelf life issues due to aqueous components and inadequate pleasurable sensation delivery.
Innovation Solution
A nicotine delivery product is created by reacting a nicotine/cation exchange resin complex with an organic polyol in an aqueous solution and drying the mixture, resulting in a product with a nicotine release rate of at least 80% over 10 minutes, using a cation exchange resin and polyol combination that enhances ion exchange and humectant properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If an aqueous solution is used in the nicotine delivery product, then nicotine release rate is improved, but shelf life deteriorates due to water causing the drug to become unbound
Solution Approach 1:
The patent changes the physical-chemical parameters of the system by introducing a polyol component that modifies the interaction between water and the nicotine-cation exchange resin complex. The polyol alters the hydration characteristics and binding stability, allowing the system to maintain both high nicotine release rates and extended shelf life by adjusting the chemical environment rather than simply adding or removing water
Solution Approach 2:
The invention creates a composite material system consisting of cation exchange resin, nicotine, water, and polyol components. This composite structure allows the polyol to mediate between the conflicting requirements of aqueous nicotine release and stable shelf life, with the polyol forming a complex with the resin-nicotine-water system that simultaneously enhances release kinetics and stabilizes the drug-bound state during storage
2Productivity
If nicotine is released quickly into the mouth, then therapeutic effect is achieved, but pleasurable sensation of smoking is not sufficiently induced
Solution Approach 1:
The patent modifies the release profile parameters by adjusting the polyol concentration and type, which changes the kinetics of nicotine release. This allows optimization of the release rate to achieve both rapid therapeutic effect and sustained pleasurable sensation by controlling the temporal distribution of nicotine delivery rather than simply increasing total release量
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The product achieves a higher nicotine release rate compared to previous methods while maintaining therapeutic nicotine loading capacity and reducing dust and handling issues, making it suitable for smoking substitution devices like chewing gum.
Implementation Method 1
a nicotine delivery product comprising nicotine, a cation exchange resin and a polyol... having a nicotine release rate of at least 80% over a 10 minute period
Implementation Method 2
there is no disclosure of a polyol in intimate contact with a nicotine/cation exchange resin complex... reducing dust and handling issues
Data Source
AI summary
A nicotine delivery product comprising the reaction product of a nicotine/cation exchange resin complex and an organic polyol; and a method for preparing it comprising (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and (b) removing water from the mixture to produce said nicotine delivery product. The nicotine delivery product has a nicotine release rate of at least 80% over a 10 minute period. It is particularly suited for use in smoking substitution devices delivering nicotine such as chewing gum, patches, lozenges, melting tablets and tablets for chewing.