Nicotine Salt Aerosol Composition Reducing Harshness
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Solution Overview
Problem
Current non-combustible aerosol provision systems face challenges in creating a satisfying inhalable aerosol with improved sensory attributes, as existing compositions often result in harshness, and there is a need for a formulation that balances nicotine content, gelling agents, aerosol-formers, and acids to enhance user experience.
Innovation Solution
Aerosol-generating compositions comprising 1-30 wt% nicotine, 15-80 wt% gelling agent, 10-60 wt% aerosol-former material, and 1-30 wt% acid, with a molar ratio of nicotine to acid at 2.2:1 or less, which also include optional nicotine salt and filler, are developed to improve sensory attributes by reducing harshness and enhancing user satisfaction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nicotine is included in the aerosol-generating composition, then the user satisfaction and sensory attributes are improved, but the harshness of the aerosol increases
Solution Approach 1:
An acid is introduced as an intermediary substance that reacts with nicotine to form a nicotine salt. This nicotine salt acts as a mediator that delivers the desired nicotine effect while significantly reducing the harshness associated with free nicotine. The acid serves as a chemical intermediary that transforms nicotine into a more user-friendly form.
Solution Approach 2:
The chemical form of nicotine is changed from free base nicotine to nicotine salt through controlled chemical reaction. By adjusting the molar ratio of nicotine to acid (2.2:1 or less), the patent optimizes the conversion efficiency while controlling the formation of nicotine salt, thereby reducing harshness while maintaining user satisfaction.
2Object-affected harmful factors
If the molar ratio of nicotine to acid is reduced to 2.2:1 or less, then the harshness is reduced and sensory attributes are improved, but the nicotine delivery efficiency may be compromised
Solution Approach 1:
Instead of using a stoichiometric 1:1 ratio of nicotine to acid, the patent employs a controlled excess of nicotine (molar ratio 2.2:1 or less). This partial excess ensures complete conversion of acid to nicotine salt while maintaining adequate free nicotine for effective delivery, optimizing both harshness reduction and nicotine delivery efficiency.
Solution Approach 2:
The patent optimizes the molar ratio parameter to balance two competing requirements: enough acid to convert nicotine to less harsh salt form, but not so much acid that nicotine delivery is compromised. The specific ratio of 2.2:1 or less represents an optimized parameter that simultaneously achieves harshness reduction and maintains delivery efficiency.
3Reliability
If gelling agent and aerosol-former material are used in optimized ratios, then the aerosol generation performance is improved, but the formulation complexity increases
Solution Approach 1:
The patent establishes specific weight percentage ranges for gelling agent (15-80 wt%) and aerosol-former material (10-60 wt%) to optimize aerosol generation performance. These parameter specifications provide clear formulation guidelines that simplify the development process while ensuring reliable aerosol generation, transforming a complex formulation challenge into a manageable parameter optimization problem.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The proposed compositions effectively reduce harshness and improve the sensory attributes of the aerosol, making it more satisfying for users by protonating nicotine to form a nicotine salt in situ, resulting in a more pleasant inhalable aerosol.
Implementation Method 1
The proposed compositions effectively reduce harshness and improve the sensory attributes of the aerosol, making it more satisfying for users by protonating nicotine to form a nicotine salt in situ
Data Source
AI summary
An aerosol-generating material having aerosol generating compositions, consumables for use within a non-combustible aerosol provision system and non-combustible aerosol provision systems. The consumables can include the aerosol-generating composition. The aerosol-generating composition can include an aerosol-generating material, wherein the aerosol-generating material includes about 1 to about 30 wt % nicotine, about 15 to about 80 wt % gelling agent, about 10 to about 60 wt % aerosol-former material, about 1 to about 30 wt % acid; and optionally filler, wherein the molar ratio of nicotine to acid is 2.2:1 or less.