Fast-Disintegrating Nicotine Tablet for Rapid Oral Absorption

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Solution Overview

Problem

Existing nicotine-releasing tablets fail to effectively emulate the smoking experience of a cigarette, leading to unpleasant throat burning and inefficient nicotine absorption due to slow disintegration and release profiles.

Innovation Solution

A fast-disintegrating nicotine tablet formulation designed to disintegrate within 60 seconds, incorporating a pH-regulating agent and nicotine salt, optimizing nicotine concentration and pH in the oral cavity for rapid absorption.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If nicotine is released slowly to the oral cavity, then burning sensation is reduced, but nicotine absorption efficiency decreases and user compliance deteriorates

Engineering Contradiction:

Improveburning sensationVSAvoidnicotine absorption efficiency

Core Design Contradiction:

Object-affected harmful factorsVSProductivity

Solution Approach 1:

The tablet is pre-formulated with optimized pH and disintegrant composition to ensure rapid disintegration within 60 seconds upon contact with saliva, creating immediate high nicotine concentration before the user can swallow or spit, thereby preventing burning while maximizing absorption

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent optimizes the pH of the tablet formulation to a specific range that prevents throat burning while enhancing nicotine permeability across the buccal mucosa, and controls disintegration time through disintegrant selection and compression force parameters

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If nicotine concentration in the oral cavity is increased, then craving relief effectiveness improves, but burning sensation in the throat worsens

Engineering Contradiction:

Improvenicotine concentrationVSAvoidburning sensation

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent adjusts the pH parameter of the oral environment through tablet formulation to optimize nicotine permeability and reduce irritation, allowing high nicotine concentrations to be delivered without causing burning sensation

Inventive Principle:

Principle #35Parameter changes

3Duration of action of moving object

If tablet disintegration time is extended, then nicotine release is more controlled, but user compliance deteriorates due to saliva generation requiring spitting or swallowing

Engineering Contradiction:

Improvetablet disintegration timeVSAvoiduser compliance

Core Design Contradiction:

Duration of action of moving objectVSEase of operation

Solution Approach 1:

The tablet is designed to complete disintegration within 60 seconds, pre-establishing the high nicotine concentration environment before saliva accumulation reaches levels that would require spitting or swallowing, thereby ensuring complete nicotine absorption

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The rapid disintegration mechanism allows the tablet to quickly pass through the critical phase where saliva generation would interfere with nicotine absorption, delivering the nicotine dose before the user needs to swallow or spit

Inventive Principle:

Principle #21Skipping (Rushing through)

4Strength

If compression force is increased to improve tablet hardness, then tablet strength improves, but disintegration time increases

Engineering Contradiction:

Improvetablet hardnessVSAvoiddisintegration time

Core Design Contradiction:

StrengthVSDuration of action of moving object

Solution Approach 1:

The patent optimizes the compression force parameter within a specific range to achieve the balance between tablet hardness for handling and rapid disintegration, and selects disintegrants with properties that facilitate quick breakdown at moderate compression forces

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20260014135A1Nicotine tablet

Publication Date: 2026.01.15 FERTIN PHARMA AS

AI summary

The invention relates to an orally disintegrating nicotine tablet for nicotine craving relief comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine and a pH regulating agent.