Nicotine Tablet with Dual Sugar Alcohol Particles for Mouthfeel
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Solution Overview
Problem
Existing oral delivery vehicles containing nicotine often compromise on convenience and taste, as they are limited by the technical feasibility of using direct compressible erythritol, which does not provide an attractive salivation effect and mouthfeel.
Innovation Solution
The use of non-directly compressible erythritol in combination with other sugar alcohols, such as sorbitol, to create a tablet with a high erythritol content that enhances salivation and taste, while maintaining mechanical stability and fast disintegration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If direct compressible erythritol is used in the tablet, then the mechanical stability is improved, but the salivation effect and mouthfeel deteriorate
Solution Approach 1:
The tablet is segmented into two distinct particle populations: direct compressible erythritol particles (at least 10% by weight) providing mechanical stability, and further sugar alcohol particles (at least 10% by weight, different composition) providing salivation effect. This segmentation allows each component to fulfill its specific function without compromising the other.
Solution Approach 2:
Different regions of the tablet have different functional qualities: the direct compressible erythritol particles are distributed to provide structural integrity in load-bearing regions, while the further sugar alcohol particles are distributed to provide salivation effect in contact regions with oral tissues. Each particle type is optimized for its local function.
2Ease of operation
If non-directly compressible erythritol is used to enhance salivation effect, then the mouthfeel is improved, but the mechanical stability deteriorates
Solution Approach 1:
The invention merges two previously separate functional components into a single tablet formulation: direct compressible erythritol for mechanical stability and further sugar alcohol particles for salivation effect. The combination is achieved through co-compression of both particle types, creating a unified tablet that delivers both functions simultaneously.
Solution Approach 2:
The tablet is a composite material system consisting of two distinct sugar alcohol particle populations with different functional properties. The direct compressible erythritol forms the structural matrix, while the further sugar alcohol particles are embedded within this matrix to provide the salivation effect, creating a functionally composite tablet.
3Ease of operation
If high sugar alcohol content is used to improve taste and salivation, then the user experience is improved, but the tablet complexity increases
Solution Approach 1:
The invention changes the compositional parameters by specifying minimum thresholds (at least 10% by weight each) for the two particle types rather than requiring precise formulations. This parameter-based approach simplifies manufacturing while ensuring the desired functional effects are achieved through the high sugar alcohol content (40-100% total).
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides an attractive mouthfeel and taste, effectively masking the bitterness of nicotine and other chemical substances, with improved salivation and faster dissolving of sugar alcohols, enhancing user experience.
Implementation Method 1
the particles consisting of erythritol serves as a means for salivation which is both attractive to the user and also serves for the purpose of dissolving the further sugar alcohol particles when the tablet is chewed as fast as possible
Data Source
AI summary
The invention relates an oral delivery vehicle tablet containing nicotine, the delivery vehicle tablet being formed by compression of a plurality of particles, the oral delivery vehicle tablet comprising nicotine, the oral delivery vehicle tablet comprising sugar alcohol(s) in an amount of 40 to 100% by weight of the delivery vehicle tablet, wherein at least 10% by weight of the delivery vehicle tablet comprises a plurality of particles consisting of erythritol and wherein the delivery vehicle tablet comprises a plurality of further sugar alcohol particles in an amount of at least 10% by weight of the delivery vehicle tablet, wherein said further sugar alcohol particles comprise at least one sugar alcohol and wherein said further sugar alcohols particles have a composition which is different from said particles consisting of erythritol.