NIR Spectroscopy Blood Glucose Prediction via Subject-Specific Model Segmentation

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Solution Overview

Problem

Conventional non-invasive methods for predicting blood glucose concentration using near-infrared spectroscopy face challenges due to variability in calibration values across individuals, leading to inaccurate predictions.

Innovation Solution

A method and system that utilize near-infrared spectroscopy to receive spectral data, classify it into predetermined labelled classes, determine best fit prediction models based on historical data, and calculate blood compound concentrations using these models for accurate prediction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If conventional non-invasive methods use a single reference calibration value for predicting glucose concentration, then the measurement process is simple, but the prediction accuracy deteriorates due to inter-individual variability

Engineering Contradiction:
Improvemeasurement process simplicityVSAvoidglucose concentration prediction accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The patent segments the calibration process by creating multiple subject-specific prediction models instead of using a single universal calibration curve. Each subject receives personalized calibration, dividing the general population into individual segments with unique spectral characteristics, thereby resolving the contradiction between operational simplicity and measurement precision.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent applies local quality by tailoring the calibration parameters to each individual subject rather than using uniform calibration for all. Each subject's spectral data is processed with subject-specific parameters, making the calibration locally optimized for individual anatomical and physiological variations, thus improving accuracy without significantly complicating the overall measurement process.

Inventive Principle:
Principle #3Local quality

2Measurement precision

If multiple subject-specific prediction models are developed to improve accuracy, then measurement precision improves, but device complexity increases

Engineering Contradiction:
Improveglucose concentration prediction accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies preliminary action by performing subject-specific calibration during an initial phase before actual glucose monitoring. The system collects spectral data and establishes personalized prediction models in advance, so that during routine monitoring, the pre-established models are simply applied without requiring complex real-time processing, thus achieving high accuracy while managing device complexity.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent uses copying by creating replicated prediction models for each subject based on their spectral characteristics. Instead of implementing a single complex universal model, the system generates simplified copies of the prediction algorithm tailored to each individual, reducing the computational complexity required during actual measurement while maintaining high precision through subject-specific parameter sets.

Inventive Principle:
Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system provides accurate and subject-specific predictions of blood compound concentrations by employing classification and prediction models tailored to individual subjects, enhancing the reliability of glucose monitoring.

Implementation Method 1

receiving, by a system, spectral data associated with a region of the target, using near-infrared (NIR) spectroscopy

Methodology Applied
Scientific EffectNear-infrared spectroscopy: Absorption Spectroscopy

Data Source

PatentUS11796465B2Method and system for predicting blood compound concentration of a target
Publication Date: 2023.10.24 SAMSUNG ELECTRONICS CO LTD
  • US11796465B2 patent drawing
  • US11796465B2 patent drawing
  • US11796465B2 patent drawing

AI summary

A method of predicting a blood compound concentration of a target may include receiving, by a system, spectral data associated with a region of the target, using near-infrared (NIR) spectroscopy. The method may include classifying, by the system, each of the plurality of data instances of the spectral data to one of a plurality of labelled classes. The method may include obtaining, by the system, one or more best fit models from a plurality of prediction models based on the classification. The method may include determining, by the system, blood compound concentration values corresponding to each of the one or more best fit models. The method may include predicting, by the system, the blood compound concentration of the target using the blood compound concentration values predicted using the best fit models.