Near-Infrared Spectroscopy MRI Index Estimation

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Solution Overview

Problem

Current MRI devices are costly and difficult to use for frequent measurements, making it challenging to repeatedly measure MRI indexes such as ADC and FA, especially for high-risk infants.

Innovation Solution

An MRI index estimation method and biometric device that uses near-infrared spectroscopy to estimate MRI indexes based on the scattering coefficient, allowing for non-invasive and cost-effective measurements by correlating the scattering coefficient with MRI indexes like ADC and FA.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If MRI device is used to measure MRI indexes, then measurement precision is improved, but cost and device complexity increase

Engineering Contradiction:
ImproveMRI index measurement accuracyVSAvoidMRI device complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent creates a simplified optical copy model that replicates the measurement functionality of MRI by using near-infrared light scattering properties. Instead of using the complex MRI device, the invention uses an optical system with light sources and detectors to measure scattering coefficients that correlate with MRI indexes, thereby achieving similar measurement objectives with a simpler device

Inventive Principle:
Principle #26Copying

Solution Approach 2:

The patent replaces the mechanical and electromagnetic system of MRI with an optical system. By substituting the complex MRI measurement mechanism with near-infrared spectroscopy that measures light scattering in tissue, the invention achieves MRI index estimation through optical properties rather than magnetic resonance, significantly reducing device complexity while maintaining measurement capability

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If MRI device is used for frequent measurement, then measurement frequency is improved, but cost increases

Engineering Contradiction:
ImproveMeasurement frequencyVSAvoidMeasurement cost
Core Design Contradiction:
ProductivityVSLoss of energy

Solution Approach 1:

The patent employs a cost-effective optical measurement system that can be used repeatedly without the high costs associated with MRI. The near-infrared spectroscopy device uses inexpensive light sources and detectors that can perform frequent measurements on high-risk infants without incurring significant costs, making it suitable for repeated monitoring

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent changes the measurement parameter from magnetic resonance signals to optical scattering coefficients. By measuring near-infrared light scattering properties that correlate with tissue microstructure, the system achieves MRI index estimation through a different physical parameter that can be measured more economically and frequently

Inventive Principle:
Principle #35Parameter changes

3Ease of operation

If simple measurement method is used, then ease of operation is improved, but measurement precision deteriorates

Engineering Contradiction:
ImproveMeasurement simplicityVSAvoidMRI index accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The patent introduces light scattering coefficient as an intermediary parameter that bridges the simple optical measurement and the complex MRI index. By measuring the scattering of near-infrared light through tissue, the system obtains an intermediate optical property that correlates with MRI indexes, allowing simple measurement methodology to yield accurate clinical information through this intermediary relationship

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables simple and frequent measurement of MRI indexes at a lower cost compared to traditional MRI devices, facilitating regular monitoring of high-risk infants.

Implementation Method 1

a scattering coefficient obtaining unit for obtaining a scattering coefficient of the measurement site or a parameter having a correlation with the scattering coefficient by a near-infrared spectroscopy based on a detection result in the light detection unit

Methodology Applied
Scientific EffectNear-infrared spectroscopy: Absorption Spectroscopy

Implementation Method 2

there exists a significant correlation between scattering coefficient of a measurement site obtained by near-infrared spectroscopy and MRI index

Methodology Applied
Scientific EffectLight scattering: Scattering

Data Source

PatentEP3097862B1MRI index estimation method, and biometric device
Publication Date: 2019.08.21 HAMAMATSU PHOTONICS KK
  • EP3097862B1 patent drawingFigure 1
  • EP3097862B1 patent drawingFigure 2
  • EP3097862B1 patent drawingFigure 3

AI summary

In the estimation method, MRI indexes (such as ADC and FA) are estimated based on a scattering coefficient µs' of a measurement site B or a parameter having a correlation with the scattering coefficient µs', the scattering coefficient µs' being obtained by a near-infrared spectroscopy based on a detection result of near-infrared light made incident on the measurement site B and propagated inside the measurement site B. The method allows acquisition of MRI index of a measurement site more simply as compared with MRI.