Miniaturized Near-Infrared Spectroscope for Tissue Phase Delay Measurement

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Conventional near-infrared spectroscopy systems for measuring phase delay and amplitude in animal tissue are bulky and power-intensive, limiting their portability and practicality for continuous monitoring.

Innovation Solution

A miniaturized system that includes a modulatable optical source, local and reference oscillators, synchronization system, optical detector, signal processing unit, and digital converters, which modulates and processes near-infrared signals to measure phase delay and amplitude, optionally integrated into a compact integrated circuit consuming less than 50 milliwatts of power and occupying a small volume.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional near-infrared spectroscopy systems are used to measure phase delay and amplitude in animal tissue, then measurement precision is maintained, but device complexity and power consumption increase significantly

Engineering Contradiction:
Improvephase delay and amplitude measurement precisionVSAvoidsystem bulkiness
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent combines multiple signal processing functions (modulation, detection, phase delay measurement, amplitude detection, and digital conversion) into a single integrated circuit. This merging of previously separate components resolves the technical contradiction by maintaining measurement precision while significantly reducing device complexity and bulkiness, enabling portable near-infrared spectroscopy systems

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The integrated circuit performs multiple functions simultaneously: it modulates the optical source, detects the returned signal, measures phase delay, measures amplitude, and converts signals to digital format. This multi-functionality allows the system to maintain comprehensive measurement capabilities while reducing the number of separate components, thereby resolving the contradiction between measurement precision and device complexity

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If conventional near-infrared spectroscopy systems are used to measure phase delay and amplitude in animal tissue, then measurement precision is maintained, but power consumption increases significantly

Engineering Contradiction:
Improvephase delay and amplitude measurement precisionVSAvoidpower consumption
Core Design Contradiction:
Measurement precisionVSUse of energy by moving object

Solution Approach 1:

The patent combines multiple signal processing functions (modulation, detection, phase delay measurement, amplitude detection, and digital conversion) into a single integrated circuit. This merging of previously separate components resolves the technical contradiction by maintaining measurement precision while significantly reducing device complexity and bulkiness, enabling portable near-infrared spectroscopy systems

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The integrated circuit is designed to be self-contained, with all necessary signal processing functions implemented within the single chip. This self-service architecture eliminates the need for external processing components, reducing overall power consumption while maintaining measurement precision, thereby resolving the contradiction between measurement accuracy and energy usage

Inventive Principle:
Principle #25Self-service

3Measurement precision

If conventional near-infrared spectroscopy systems are used, then adequate signal processing capability is achieved, but the system occupies significant volume

Engineering Contradiction:
Improvetissue analysis precisionVSAvoidsystem volume
Core Design Contradiction:
Measurement precisionVSVolume of moving object

Solution Approach 1:

The patent combines multiple signal processing functions (modulation, detection, phase delay measurement, amplitude detection, and digital conversion) into a single integrated circuit. This merging of previously separate components resolves the technical contradiction by maintaining measurement precision while significantly reducing device complexity and bulkiness, enabling portable near-infrared spectroscopy systems

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The integrated circuit implements a nested architecture where multiple functional blocks (modulator, detector, phase delay measurer, amplitude detector, and ADC) are contained within a single chip. This nesting of functions at the circuit level dramatically reduces the physical volume of the system while preserving all necessary measurement capabilities

Inventive Principle:
Principle #7Nested doll (Nesting)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables a portable, low-power near-infrared spectroscope for precise tissue analysis, facilitating point-of-care diagnosis and prolonged monitoring without the bulkiness and high power consumption of traditional systems.

Implementation Method 1

a modulatable optical source providing an optical output in the near infrared frequency range, configured to be mounted to radiate into the tissue

Methodology Applied
Scientific EffectLight emission and modulation: Light

Implementation Method 2

an optical detector, configured to be mounted to receive an optical signal emanating from the tissue and providing an electrical signal output as a result of receiving the optical signal

Methodology Applied
Scientific EffectPhotoelectric effect: Photoelectric Effect

Implementation Method 3

a signal derived from the signal output of the optical detector is heterodyned with the local oscillator to produce a first intermediate frequency signal

Methodology Applied
Scientific EffectHeterodyning: Heterodyne

Data Source

PatentUS10561319B2System and method for measuring phase delay and amplitude of an optical signal in animal tissue
Publication Date: 2020.02.18 TUFTS UNIV
  • US10561319B2 patent drawing
  • US10561319B2 patent drawing
  • US10561319B2 patent drawing

AI summary

A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate by processing a signal from an optical detector and a corresponding signal from an optical detector emulation circuit. In some aspects, the processed signals are fed into a phase delay detection system that provides an output thereof a digital measure of the phase delay of the received optical signal.