NiTi Thin-Film Flow Diverter for Aneurysm Occlusion
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Solution Overview
Problem
Current treatments for cerebral aneurysms, such as surgical clipping and endovascular coiling, have limitations including invasiveness, technical challenges, and the need for costly and complex devices that may not be suitable for all aneurysm types.
Innovation Solution
A minimally invasive interventional system using a blood flow diverting implant made from nickel-titanium (NiTi) thin-film, which can be deployed through a microcatheter with an outer diameter of 0.027 inches or less, and includes a restraint mechanism for accurate positioning and deployment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If surgical clipping is used to treat cerebral aneurysms, then effective occlusion is achieved, but the procedure becomes invasive and technically challenging
Solution Approach 1:
The patent replaces the mechanical surgical clipping system with an endovascular delivery system that uses a microcatheter to deliver a flow diverter implant through the bloodstream. This substitution eliminates the need for craniotomy and direct mechanical clipping, achieving occlusion through hemodynamic redirection rather than physical clamping.
Solution Approach 2:
The patent introduces a flow diverter implant as an intermediary device that redirects blood flow away from the aneurysm sac. This intermediary mechanism achieves occlusion indirectly by altering flow patterns rather than directly blocking the aneurysm opening, thereby avoiding the invasiveness of surgical clipping.
2Ease of operation
If endovascular coiling is used to treat cerebral aneurysms, then minimally invasive treatment is achieved, but the device complexity and cost increase
Solution Approach 1:
The patent employs a thin-film flow diverter implant that can be compressed into a compact form for delivery through a small-bore microcatheter. The thin-film structure provides flexibility for navigation through tortuous vasculature while maintaining structural integrity upon deployment, reducing both device complexity and delivery system size.
Solution Approach 2:
The patent divides the flow diverter implant into a mesh structure with interconnected struts and spaces, allowing the device to be compressed for delivery and then expand to its functional configuration. This segmentation enables minimally invasive delivery while maintaining the structural complexity needed for effective flow diversion.
3Ease of operation
If current endovascular devices are used, then treatment is less invasive, but the devices are costly and not suitable for all aneurysm types
Solution Approach 1:
The patent designs a flow diverter implant with a configurable mesh structure that can be adapted to treat various aneurysm types including wide-necked aneurysms, fusiform aneurysms, and aneurysms in different vascular locations. The same basic device platform can be customized through mesh density, strut configuration, and overall dimensions to address diverse clinical scenarios.
Solution Approach 2:
The patent utilizes parameters such as mesh pore size, strut thickness, and device dimensions that can be adjusted to match different aneurysm characteristics. By varying these parameters, the same fundamental device design can be optimized for different aneurysm sizes, shapes, and locations, enhancing versatility without increasing base device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides effective blood flow diversion and occlusion of the aneurysm, reducing the risk of hemorrhagic stroke while being minimally invasive and cost-effective, with the ability to navigate complex neurovascular anatomy.
Implementation Method 1
A microcatheter delivery system is provided for delivering a thin-film, mesh structure for occluding an aneurysm. The mesh structure may be made from a shape memory material such as nickel-titanium (NiTi).
Implementation Method 2
The mesh structure may be made from a shape memory material such as nickel-titanium (NiTi). The mesh structure can be compressed into a compressed configuration that allows the mesh structure to be delivered to a target site within a patient's body via the microcatheter.
Data Source
AI summary
The present disclosure is related to an occlusion device having a mesh structure. The occlusion device configured to transition between a two-dimensional configuration and a three-dimensional configuration. In the two-dimensional configuration and at rest, the occlusion device is flat or planar. In the three-dimensional configuration, the occlusion device defines an internal volume.