Nitric Oxide Gel Composition With NO2 Inhibition and Dose Control

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Solution Overview

Problem

Existing methods for administering nitric oxide are inconvenient, expensive, or difficult, and current formulations of acidified nitrite gels generate equal amounts of harmful nitrogen dioxide, compromising the delivery of precise nitric oxide dosages and lung safety.

Innovation Solution

The addition of sodium bentonite to the nitrite and citric acid mixture stabilizes the viscosity of the gel, inhibits nitrogen dioxide formation, and enhances the production of nitric oxide, using a gas analyzer with a metering circuit and sensor array to control nitric oxide concentration in a blended gas mix.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional acidified nitrite gels are used to generate nitric oxide, then nitric oxide can be administered therapeutically, but harmful nitrogen dioxide is generated in equal amounts compromising lung safety

Engineering Contradiction:

Improvenitric oxide productionVSAvoidnitrogen dioxide generation

Core Design Contradiction:

Quantity of substanceVSObject-generated harmful factors

Solution Approach 1:

The patent applies the principle of converting harm into benefit by using sodium bentonite to react with and convert the harmful nitrogen dioxide generated during nitric oxide production into beneficial or harmless substances. The bentonite clay absorbs and neutralizes the harmful NO2 gas, transforming it from a harmful byproduct into a controlled component of the therapy system.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

Sodium bentonite serves as an intermediary substance between the nitric oxide generation process and the respiratory system. It mediates the interaction by absorbing and filtering the harmful nitrogen dioxide while allowing the therapeutic nitric oxide to pass through to the patient's lungs, thus protecting the patient from harmful effects while maintaining therapeutic benefits.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If conventional nitric oxide administration methods are used, then therapy can be provided, but the methods are inconvenient, expensive, or difficult

Engineering Contradiction:

Improvetherapy effectivenessVSAvoidadministration convenience

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent applies self-service by enabling the system to automatically monitor and adjust nitric oxide delivery based on real-time feedback from sensors. The system self-regulates the concentration and flow rate of nitric oxide without requiring constant manual intervention, making the therapy more convenient and easier to operate while maintaining reliability.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent incorporates feedback mechanisms using sensors to continuously monitor the nitric oxide concentration and nitrogen dioxide levels in the delivered gas mixture. This feedback information is used to automatically adjust the nitric oxide delivery parameters, ensuring consistent and reliable therapy while simplifying operation through automated control.

Inventive Principle:

Principle #23Feedback

3Manufacturing precision

If precise nitric oxide dosing is attempted with current formulations, then therapeutic benefit can be achieved, but the delivery of precise dosages is compromised due to nitrogen dioxide formation

Engineering Contradiction:

Improvenitric oxide dosage precisionVSAvoidnitrogen dioxide interference

Core Design Contradiction:

Manufacturing precisionVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful nitrogen dioxide interference into a controlled parameter by using sodium bentonite to absorb and neutralize it. This transformation allows the system to achieve precise nitric oxide dosing because the harmful NO2 is converted into a manageable component that does not interfere with the dosing accuracy.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

Sodium bentonite acts as an intermediary that protects the precise dosing process from nitrogen dioxide interference. It filters and neutralizes the harmful NO2 molecules, creating a clean delivery path that allows for accurate and reliable nitric oxide dosing without contamination from harmful byproducts.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system ensures safe and precise delivery of nitric oxide by stabilizing gel viscosity and reducing nitrogen dioxide, allowing affordable and effective nitric oxide therapy for various medical conditions.

Implementation Method 1

The addition of sodium bentonite to the nitrite and citric acid mixture stabilizes the viscosity of the gel

Methodology Applied

Scientific EffectViscosity stabilization:

Implementation Method 2

inhibits nitrogen dioxide formation

Methodology Applied

Scientific EffectGas absorption: Absorption (physical)

Implementation Method 3

combining sodium nitrite and an organic acid... When mixed, they produce NO gas

Methodology Applied

Scientific EffectChemical reaction: Chemical Bonding

Implementation Method 4

a gas sampling circuit comprising a sensor array. The sampling circuit can be configured to sample the blended gas mix to determine concentrations of gases in the blended gas mix

Methodology Applied

Scientific EffectGas detection:

Implementation Method 5

a nitric oxide metering circuit comprising a metering valve. The metering circuit can be configured to meter a flow of nitric oxide into a blended gas mix

Methodology Applied

Scientific EffectFlow metering:

Data Source

PatentUS20260007694A1Stabilized and no2-inhibited nitric oxide generating compositions for nitric oxide therapy

Publication Date: 2026.01.08 MILLER J W RANDOLPH

AI summary

The present invention relates to stabilized and NO2-inhibited nitric oxide generating gels for nitric oxide therapy, for the treatment of bacterial, viral or fungal conditions, including the formulas for the gels with new stabilizing ingredients/agents, together with delivery instructions that can permit self-administration of the gas, new dosage protocols for the use of the nitric oxide gas, and new drug concentrations for enhanced effectiveness. Liquid compositions for treatment of various conditions and saturation of articles are also described, along with other implementations.