Nitric Oxide Gel Formulation With NO2 Conversion and Viscosity Stability

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Solution Overview

Problem

Existing methods for administering nitric oxide are inconvenient, expensive, or difficult, and current formulations of acidified nitrite gels generate equal amounts of harmful nitrogen dioxide, compromising the delivery of precise nitric oxide dosages due to viscosity issues and nitrogen dioxide formation.

Innovation Solution

Incorporating sodium bentonite into the gel formulation stabilizes viscosity and converts nitrogen dioxide into nitric oxide, using sodium nitrite and citric acid to produce nitric oxide and nitrogen dioxide, and employing a gas analyzer with a metering circuit and sensor array to control nitric oxide concentration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If acidified nitrite gels are used to generate nitric oxide, then nitric oxide can be delivered therapeutically, but harmful nitrogen dioxide is generated in equal amounts compromising safety

Engineering Contradiction:

Improvenitric oxide deliveryVSAvoidnitrogen dioxide formation

Core Design Contradiction:

Quantity of substanceVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful nitrogen dioxide byproduct into beneficial nitric oxide through chemical reaction. Sodium bentonite catalyzes the conversion of nitrogen dioxide to nitric oxide, transforming the harmful substance into the desired therapeutic gas, thereby eliminating the harmful effect while maintaining the beneficial nitric oxide delivery function.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

Sodium bentonite acts as an intermediary substance that facilitates the conversion of nitrogen dioxide to nitric oxide. It mediates the chemical reaction between the acidified nitrite gel components, enabling the transformation of the harmful byproduct into the beneficial therapeutic gas without requiring direct human intervention.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Quantity of substance

If acidified nitrite gels are used to generate nitric oxide, then nitric oxide can be delivered, but viscosity issues compromise precise dosage delivery

Engineering Contradiction:

Improvenitric oxide deliveryVSAvoidgel viscosity

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent changes the physical-chemical parameters of the gel formulation by incorporating sodium bentonite. This additive modifies the viscosity and stability characteristics of the gel, enabling precise control over nitric oxide generation and delivery while maintaining the therapeutic effectiveness of the formulation.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If conventional nitric oxide administration methods are used, then therapy can be provided, but the methods are inconvenient, expensive, or difficult

Engineering Contradiction:

Improvetherapy effectivenessVSAvoidadministration convenience

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent enables the gel formulation to generate nitric oxide autonomously through its chemical composition and sodium bentonite-catalyzed reaction. The system is self-sufficient, eliminating the need for complex external equipment and manual intervention required by conventional methods, thereby improving ease of operation while maintaining therapeutic reliability.

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides a stable and safe delivery of nitric oxide by stabilizing gel viscosity and converting nitrogen dioxide to nitric oxide, ensuring precise dosages without harmful by-products, making the therapy affordable and accessible worldwide.

Implementation Method 1

Incorporating sodium bentonite into the gel formulation stabilizes viscosity

Methodology Applied

Scientific EffectViscosity stabilization:

Implementation Method 2

converts nitrogen dioxide into nitric oxide

Methodology Applied

Scientific EffectChemical conversion:

Implementation Method 3

using sodium nitrite and citric acid to produce nitric oxide and nitrogen dioxide

Methodology Applied

Scientific EffectChemical reaction:

Data Source

PatentUS20260062296A1Stabilized and no2-inhibited nitric oxide generating GELS for inhaled nitric oxide therapy

Publication Date: 2026.03.05 MILLER J W RANDOLPH

AI summary

The present invention relates to stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy, for the treatment of bacterial, viral or fungal conditions, including the formulas for the gels with new stabilizing ingredients/agents, together with delivery instructions that can permit self-administration of the gas, new dosage protocols for the use of the nitric oxide gas, and new drug concentrations for enhanced effectiveness. Other implementations are described.