Nitric Oxide Composition for Antiviral Immunity and Oxidative Stress
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Solution Overview
Problem
Current treatments for viral infections and sepsis are inadequate, with existing antiviral drugs showing resistance and side effects, and there is a lack of effective methods to modulate the immune response to manage inflammation and oxidative stress effectively.
Innovation Solution
A pharmaceutical composition comprising 5-methyltetrahydrofolic acid, arginine, and optionally dehydroascorbic acid or NMN, which acts as an NO toxicity decreasing agent and extender to produce a safe and sufficient amount of nitric oxide, regulating immune response and reducing peroxynitrite levels without inhibiting iNOS expression.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antiviral drugs are used to treat viral infections, then virus inhibition effect is achieved, but drug resistance and side effects occur
Solution Approach 1:
The patent converts the harmful overproduction of nitric oxide (which causes oxidative stress and inflammation) into a beneficial therapeutic effect by using antioxidants to modulate its levels. The composition transforms the double-edged sword of nitric oxide into a controlled immune modulator that enhances antiviral immunity while preventing excessive inflammation and drug resistance
Solution Approach 2:
The patent introduces antioxidants (vitamin C, vitamin E, glutathione) as intermediary substances that mediate between the immune system's nitric oxide production and the host tissue. These intermediaries scavenge excess free radicals and peroxynitrite, allowing the immune system to maintain effective antiviral response without the harmful side effects of uncontrolled oxidative stress
2Reliability
If nitric oxide is increased to enhance immune response, then antiviral effect is improved, but oxidative stress and inflammation increase
Solution Approach 1:
The patent changes the concentration parameters of nitric oxide and antioxidants in the composition to achieve optimal therapeutic effects. By carefully controlling the ratios of nitric oxide donors (L-arginine) to antioxidants (vitamin C, vitamin E, glutathione), the formulation maintains nitric oxide levels sufficient for antiviral immunity while preventing excessive oxidative stress through coordinated parameter adjustment
Solution Approach 2:
The patent creates a composite pharmaceutical composition that combines multiple substances with complementary functions: nitric oxide donors (L-arginine, L-citrulline), antioxidants (vitamin C, vitamin E, glutathione), and cofactors (B vitamins, zinc). This composite approach allows the system to simultaneously enhance immune response through nitric oxide while preventing oxidative damage through the synergistic action of multiple antioxidants
3Productivity
If existing antiviral drugs are used, then virus replication is inhibited, but treatment effectiveness decreases due to resistance
Solution Approach 1:
The patent enables the host immune system to self-service in fighting viral infections by providing substrates (L-arginine, L-citrulline) and cofactors (B vitamins, zinc, antioxidants) that the body needs to produce its own nitric oxide and maintain immune function. This self-service approach avoids the problems of external drug resistance by empowering the host's natural defense mechanisms rather than relying on external antiviral agents
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition enhances T cell proliferation, reduces inflammatory factors, and improves survival rates in viral infections and sepsis by promoting a balanced immune response and reducing oxidative stress, demonstrating significant antiviral and anti-inflammatory effects.
Implementation Method 1
5-methyltetrahydrofolic acid, a novel antioxidant
Implementation Method 2
pharmaceutical composition which can produce nitric oxide in an animal body
Data Source
AI summary
A pharmaceutical composition for producing a safe amount of nitric oxide (NO) in vivo and use thereof. The pharmaceutical composition comprises the following components: an NO toxicity decreasing agent, an optional NO extender, and a nitric oxide synthase inducer. Provided is the pharmaceutical composition which has high versatility and extremely effectively treats pathogenic microorganism infections. A new medicinal activity of 5-methyltetrahydrofolic acid, NMN, and dehydroascorbic acid is found, which has a variety of active effects on an immune system caused by pathogen infection, and capable of being used for treating or preventing disease caused by virus infections and other pathogen infections.