Nitric Oxide Phosphatidylcholine Matrix for Inflammatory Dermatoses
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Solution Overview
Problem
Current treatments for inflammatory dermatoses such as psoriasis, atopic dermatitis, and contact dermatitis are inadequate in effectively managing inflammation and symptoms, with existing therapies often having limitations in efficacy and side effects.
Innovation Solution
A transdermal delivery method using a composition comprising nitric oxide entrapped in a phosphatidylcholine matrix, which is applied topically to the skin to deliver nitric oxide directly to the affected areas, thereby modulating inflammatory pathways and reducing inflammation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for inflammatory dermatoses are used, then they provide some therapeutic effect, but they have limitations in efficacy and cause side effects
Solution Approach 1:
The patent uses nitric oxide as an intermediary substance delivered through a phosphatidylcholine vehicle to mediate the therapeutic effect on inflammatory dermatoses. The nitric oxide acts as a biological mediator that modulates inflammatory pathways, transcription factors, and cytokine production, providing therapeutic benefit while the phosphatidylcholine vehicle enables controlled delivery and reduces direct toxicity
Solution Approach 2:
The patent changes the physical and chemical parameters of nitric oxide delivery by entrapping it in a phosphatidylcholine matrix, which controls the release rate and local concentration. This parameter change allows sustained delivery of nitric oxide at therapeutic levels while avoiding the side effects associated with conventional high-dose or non-controlled delivery methods
2Productivity
If nitric oxide is delivered topically to achieve rapid and sustained relief, then therapeutic effectiveness is improved, but the complexity of the delivery system increases
Solution Approach 1:
The patent creates a composite material system combining nitric oxide (the therapeutic agent) with phosphatidylcholine (the delivery vehicle). This composite structure allows the nitric oxide to be entrapped and delivered in a controlled manner, achieving rapid and sustained therapeutic effects while the phosphatidylcholine component simplifies the overall delivery mechanism compared to more complex controlled-release systems
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nitric oxide delivery method provides rapid and sustained relief from inflammatory symptoms, stabilizes the disorder, and slows its progression, with the potential for long-term stability and minimal side effects due to direct targeting of inflammatory sites.
Implementation Method 1
a composition comprising an effective amount of nitric oxide and a carrier having a phosphatidylcholine component entrapping the nitric oxide
Data Source
AI summary
The present invention generally relates to compositions and methods for treatment of various inflammatory diseases, such as inflammatory dermatoses and other conditions, e.g., using nitric oxide. Examples of such dermatoses include psoriasis, atopic dermatitis, and contact dermatitis. The nitric oxide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin, e.g., onto an inflammation site, or other suitable portion of the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.