Nitric Oxide Wound Dressing Composition for Stable Single-Part Delivery
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Solution Overview
Problem
Existing wound dressings that generate nitric oxide using a nitrite salt and a proton source as separate components face issues with premature reaction during manufacturing and storage, leading to nitric oxide loss and potential dosing inaccuracies, and require complex two-part systems that are prone to use errors.
Innovation Solution
A single-part wound dressing with a nitric oxide generating layer containing a solid powder nitrite salt and a solid proton source, which remain inert until exposed to an aqueous environment, minimizing moisture exposure to prevent premature reaction and allowing for a single-piece application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If a two-part system with separate nitrite salt and acid components is used, then premature reaction during manufacturing and storage is prevented, but device complexity increases and dosing accuracy decreases due to combination errors
Solution Approach 1:
The patent combines the nitrite salt and acid components into a single wound dressing layer, eliminating the need for separate parts while maintaining stability. The components are mixed at manufacturing in controlled proportions and remain stable in dry solid form until application to the wound, where moisture triggers nitric oxide generation. This resolves the contradiction by merging parts without sacrificing stability.
2Stability of the object's composition
If a two-part system with separate nitrite salt and acid components is used, then premature reaction during manufacturing and storage is prevented, but dosing accuracy decreases due to combination errors
Solution Approach 1:
The patent performs preliminary mixing of nitrite salt and acid components in precise proportions during manufacturing, then maintains them in a stable dry state until use. The exact stoichiometric ratios are established in advance during production, eliminating dosing errors that would occur during patient application. This preliminary action ensures precise dosing while maintaining component stability.
3Device complexity
If a one-part wound dressing with mixed nitrite salt and acid is used, then manufacturing complexity and packaging are reduced, but premature reaction occurs during manufacturing and storage causing nitric oxide loss
Solution Approach 1:
The patent changes the physical state parameter of the components from liquid or aqueous to dry solid form. In this dry state, the nitrite salt and acid remain stable and do not react prematurely. Upon application to the moist wound environment, the parameters change again as moisture is absorbed, triggering controlled nitric oxide generation. This parameter change enables a simple one-part system without nitric oxide loss.
4Device complexity
If solid powder nitrite salt and solid proton source are used in close proximity, then a single-part system is achieved, but reaction initiation control becomes critical to prevent premature nitric oxide release
Solution Approach 1:
The patent uses moisture from the wound environment as an intermediary trigger to initiate the reaction between nitrite salt and acid. The components are kept in a stable dry state during storage and transport, then reliably activated only when they contact the moist wound bed. This intermediary mechanism ensures reliable reaction initiation control while maintaining the simplicity of a one-part system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a stable, single-part wound dressing that effectively generates nitric oxide only when needed, reducing manufacturing complexity, nitric oxide loss, and minimizing dosing inaccuracies while maintaining nitric oxide efficacy at the point of use.
Implementation Method 1
The acidification of nitrite salts using a proton source such as an acid to produce initially nitrous acid (HNO2), which nitrous acid then readily decomposes to nitric oxide and nitrate
Implementation Method 2
nitrous acid then readily decomposes to nitric oxide and nitrate with hydrogen ions and water
Implementation Method 3
the nitrite salt and the proton source are held in close proximity (or intimately associated) to provide acidification of the nitrite when in contact with an aqueous environment
Data Source
AI summary
A wound dressing for treating a wound, the wound dressing comprising a nitric oxide generating layer for generating nitric oxide by the acidification of a nitrite salt, wherein the nitric oxide generating layer includes a solid powder nitrite salt component and a solid proton source component, methods and uses of such a wound dressing for treating a wound.