Nitro-Oleic Acid Scaffold for Abdominal Wall Angiogenesis

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Solution Overview

Problem

Current surgical repair methods for abdominal hernias face challenges such as high recurrence rates, mesh encapsulation, mechanical mismatch, and reduced vascularity, which affect the restoration of muscle function and tissue quality in the abdominal wall.

Innovation Solution

A composite scaffold comprising dermal extracellular matrix gel, poly(ester carbonate) urethane urea fibers, and microparticles loaded with nitro oleic acid, which enhances neovascularization by controlled release of the nitro oleic acid agent, promoting tissue remodeling and angiogenesis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If prosthetic materials (synthetic or biologic) are used for abdominal wall repair, then surgical site infections and fistulas are reduced, but hernia recurrence and mesh encapsulation remain high

Engineering Contradiction:

Improvesurgical site infectionsVSAvoidhernia recurrence rate

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent employs a composite scaffold combining biodegradable polymer matrix with integrated biologic components (ECM gel) and pharmacologic agents (nitro-oleic acid microparticles). This multi-component system provides both immediate structural support to prevent hernia recurrence and controlled biological activity to promote tissue regeneration, thereby resolving the contradiction between infection prevention and long-term reliability.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The scaffold utilizes controlled degradation of the biodegradable polymer matrix over time, transitioning from a mechanically strong implant to a fully resorbed structure replaced by native tissue. This temporal parameter change allows the material to provide initial support (preventing recurrence) while gradually handing off function to regenerated tissue, eliminating the need for permanent foreign material that causes encapsulation.

Inventive Principle:

Principle #35Parameter changes

2Stability of the object's composition

If elastic biodegradable synthetic materials combined with ECM gels are used, then cellular infiltration and tissue remodeling are improved, but muscle function and vascularity are not restored to native levels

Engineering Contradiction:

Improvetissue remodelingVSAvoidmuscle function restoration

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The scaffold incorporates nitro-oleic acid microparticles that preemptively stimulate angiogenesis and vascularization during the early phases of tissue regeneration. By pre-conditioning the implantation site with pro-angiogenic factors, the scaffold ensures that blood vessels form concurrently with tissue remodeling, thereby restoring vascularity and muscle function to native levels rather than allowing these parameters to lag behind structural repair.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The nitro-oleic acid serves as a biochemical intermediary that mediates between the inert scaffold structure and the regenerative host response. This agent translates the passive mechanical support of the scaffold into active biological regeneration by stimulating endothelial cell proliferation and vascular tube formation, thereby bridging the gap between structural repair and functional restoration.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Stability of the object's composition

If synthetic meshes are combined with biologic materials for regenerative medicine, then tissue remodeling is enhanced, but reduced vascularity of the implanted volume persists

Engineering Contradiction:

Improvetissue remodeling capacityVSAvoidvascularity level

Core Design Contradiction:

Stability of the object's compositionVSQuantity of substance

Solution Approach 1:

The scaffold delivers nitro-oleic acid in a spatially controlled manner through microparticles distributed throughout the implant volume. This localized delivery ensures that pro-angiogenic stimulation occurs precisely where needed within the implanted region, creating gradients of vascularization that match the spatial distribution of tissue remodeling activity and ensuring uniform vascularity restoration throughout the entire scaffold volume.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The scaffold design significantly improves regional angiogenesis, reduces fibrotic response, and increases abdominal wall thickness, providing a more effective tissue repair solution by incorporating a bioactive component, tuning scaffold degradation, and controlling drug release.

Implementation Method 1

release of the nitro oleic acid agent enhances neovascularization at the portion of the abdominal wall

Methodology Applied

Scientific EffectControlled release:

Implementation Method 2

release of the nitro oleic acid agent enhances neovascularization at the portion of the abdominal wall

Methodology Applied

Scientific EffectNeovascularization:

Implementation Method 3

promoting tissue remodeling and angiogenesis

Methodology Applied

Scientific EffectAngiogenesis:

Data Source

PatentUS11576887B2Nitro-oleic acid controlled release platform to induce regional angiogenesis in abdominal wall repair

Publication Date: 2023.02.14 FOND RI MED

AI summary

A construct comprising a dermal extracellular matrix gel, polymer fibers, and microparticles containing a nitro oleic acid agent.