Nitrogen Monoxide-Responsive Polymeric Gel With Dissociable Crosslinks
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Solution Overview
Problem
There is a need for a material that can effectively remove nitrogen monoxide and release a drug in response to nitrogen monoxide for therapeutic uses, as well as a material that can efficiently capture nitrogen monoxide from automobile exhaust gas.
Innovation Solution
A polymeric gel with a crosslinking point derived from o-phenylenediamine that dissociates in response to nitrogen monoxide, allowing the gel to react with nitrogen monoxide to remove it and release a drug, and a method of preparing this gel by polymerizing a mixture of monofunctional hydrophilic monomers and monomers containing o-phenylenediamine residues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a polymeric gel with dissociable crosslinking points is used to respond to nitrogen monoxide, then the gel can effectively remove nitrogen monoxide and release drugs, but the mechanical strength and structural stability of the gel may be compromised
Solution Approach 1:
The crosslinking structure is segmented into dissociable crosslinking points that can selectively break in response to nitrogen monoxide, allowing the gel to respond to the target gas while maintaining overall structural integrity through the remaining crosslinked network
Solution Approach 2:
The gel undergoes parameter changes in its crosslinking density and mesh size in response to nitrogen monoxide concentration, allowing dynamic adaptation of its properties while maintaining mechanical strength through controlled dissociation rather than complete breakdown
2Stability of the object's composition
If the crosslinking structure is made highly stable to maintain mechanical strength, then the gel structure remains intact, but the gel cannot effectively release drugs or respond to nitrogen monoxide
Solution Approach 1:
The crosslinking structure is designed with dynamic dissociable crosslinking points that can reversibly break and reform, allowing the gel to transition between stable and responsive states depending on nitrogen monoxide presence, thus achieving both structural stability and drug release capability
Solution Approach 2:
The dissociable crosslinking points act as intermediaries that mediate between the stable gel matrix and the nitrogen monoxide stimulus, allowing controlled response and drug release while maintaining overall structural integrity through the persistent crosslinked network
3Strength
If the mesh size is reduced to improve mechanical strength, then the gel structure becomes more robust, but the gel cannot effectively remove nitrogen monoxide or allow drug diffusion
Solution Approach 1:
The mesh size is made dynamic through dissociable crosslinking points that can increase in response to nitrogen monoxide, allowing the gel to switch between a compact strong structure and an expanded porous structure for gas removal and drug diffusion
Solution Approach 2:
The gel undergoes parameter changes in mesh size and porosity in response to nitrogen monoxide concentration, allowing dynamic adjustment of its physical properties to simultaneously achieve mechanical strength and effective gas removal capacity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymeric gel effectively responds to nitrogen monoxide to remove it and release a drug, maintaining mechanical strength and selectively adjusting mesh size, and can be used in drug delivery systems and contact lenses to inhibit angiogenesis.
Implementation Method 1
a crosslinking point which is dissociable in response to nitrogen monoxide... the polymeric gel may react with nitrogen monoxide to remove nitrogen monoxide
Implementation Method 2
a crosslinking point which is dissociable by response to nitrogen monoxide to effectively release a drug carried inside the polymeric gel
Implementation Method 3
polymerizing a mixture of a monofunctional hydrophilic monomer and a monomer containing a plurality of functional groups including an o-phenylenediamine residue
Data Source
Figure 1a~2
Figure 3a~4d
Figure 5~6f
AI summary
The present invention relates to a polymeric gel comprising crosslink points, which are dissociated in response to nitrogen monoxide, and to a method for preparing a hydrogel, the method comprising the steps of: a) polymerizing a mixture of monomers comprising a monofunctional hydrophilic monomer and a monomer comprising a plurality of functional groups comprising an o-phenylenediamine residue; and b) separating a hydrogel formed by the polymerization.