NMNH Calcium Salt Polymorphs for Stable Moisture-Resistant Storage
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Solution Overview
Problem
NMNH, the reduced form of NMN, is unstable and sensitive to air, leading to poor stability and unsuitable for long-term storage, hindering market promotion.
Innovation Solution
Development of polymorphic forms of reduced β-nicotinamide mononucleotide calcium salt, specifically crystalline forms A, B, C, D, and E, which exhibit enhanced stability and resistance to moisture absorption, making them more suitable for long-term storage and market promotion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If NMNH is used as a precursor for NAD+ supplementation, then NAD+-promoting effects are enhanced, but stability and suitability for long-term storage deteriorate
Solution Approach 1:
The patent changes the chemical form of NMNH from free base to calcium salt, which fundamentally alters the stability parameters while preserving the NAD+-promoting biological activity. This parameter change transforms an unstable compound into a stable salt form suitable for commercialization.
Solution Approach 2:
The patent creates a composite structure by forming a salt between NMNH and calcium ions, resulting in a new compound that combines the beneficial biological effects of NMNH with the enhanced stability of calcium salts, enabling long-term storage and market promotion.
2Manufacturing precision
If NMNH disodium salt crystalline form is used, then purity is maintained, but stability under storage conditions deteriorates
Solution Approach 1:
The patent changes the salt form from disodium salt to calcium salt, which fundamentally improves the shelf-life parameter while maintaining high purity through controlled crystallization processes. The calcium salt form inherently provides better storage stability.
3Ease of manufacture
If amorphous powder form of NMNH is used, then ease of manufacture is improved, but stability and resistance to moisture absorption deteriorate
Solution Approach 1:
The patent employs crystallization processes to transition the amorphous powder form into well-defined crystalline forms of the calcium salt. This phase transition from amorphous to crystalline state dramatically improves moisture resistance and storage stability while maintaining manufacturing feasibility through controlled crystallization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The crystalline forms A, B, C, D, and E of reduced β-nicotinamide mononucleotide calcium salt demonstrate improved stability and resistance to moisture absorption, meeting shelf-life requirements for commercial products and suitable for long-term storage and market promotion.
Implementation Method 1
Development of polymorphic forms of reduced β-nicotinamide mononucleotide calcium salt, specifically crystalline forms A, B, C, D, and E, which exhibit enhanced stability and resistance to moisture absorption
Data Source
AI summary
A compound NMNH calcium salt, in particular a polymorph of a reduced β-nicotinamide mononucleotide calcium salt and a preparation method therefor, a use thereof as a pharmaceutical ingredient, a health care product ingredient and a cosmetic ingredient or as a food additive, and a formulation containing same, belonging to the field of medicines, health care products, cosmetics and food additives. For the NMNH calcium salt polymorph, the crystal thereof displays long-term continuous stability, and compared with NMNH disodium salt, has significantly superior stability performance and anti-hygroscopic properties, and is more beneficial to long-term storage, promotion and market application. The NMNH calcium salt crystal is simple in preparation process, easy to control and suitable for large-scale production.