NMNH Disodium Salt Polymorphs for Stable, Free-Flowing Crystals
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Solution Overview
Problem
The synthesis of reduced β-nicotinamide mononucleotide disodium salt (NMNH) faces challenges such as easy oxidation, poor fluidity, instability, and lack of polymorphic forms, making industrial production difficult.
Innovation Solution
Development of stable polymorphic forms of NMNH disodium salt crystals, including crystal forms A, B, and C, with improved stability, fluidity, and suitability for industrial production through controlled crystallization methods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If freeze-drying is used to obtain amorphous solid NMNH, then purity can be achieved, but the product has poor fluidity, absorbs moisture easily, becomes oil, and degrades quickly
Solution Approach 1:
The patent changes the physical state parameter from amorphous solid to crystalline solid by controlling the crystallization process. This parameter change transforms the product from a moisture-absorbing, unstable amorphous form to a stable crystalline form with good fluidity and low hygroscopicity, while maintaining high purity through controlled crystallization from solution.
Solution Approach 2:
The patent utilizes phase transition from amorphous solid to crystalline solid through controlled crystallization. By inducing controlled crystallization from aqueous solution, the product transitions from an unstable amorphous state to a stable crystalline state, improving fluidity, reducing moisture absorption, and enhancing overall stability while preserving purity.
2Measurement precision
If aqueous solution with higher purity is obtained by preparative chromatography, then purity is improved, but the product is amorphous solid with poor fluidity and foamy structure
Solution Approach 1:
The patent changes the physical structure parameter from amorphous to crystalline by controlling crystallization conditions. This parameter change improves fluidity and eliminates the foamy structure while maintaining the high purity achieved through preparative chromatography, creating a product that is both pure and easy to handle.
3Productivity
If industrial production is pursued, then productivity is improved, but energy consumption increases and production capacity is limited
Solution Approach 1:
The patent replaces the energy-intensive freeze-drying process with a controlled crystallization process from aqueous solution. This substitution eliminates the need for vacuum freezing and drying, significantly reducing energy consumption while enabling scalable industrial production with higher productivity and unlimited production capacity.
4Ease of manufacture
If amorphous solid NMNH is produced, then synthesis is simplified, but the product has high energy content and is more unstable than crystalline solids
Solution Approach 1:
The patent utilizes phase transition from amorphous to crystalline state through controlled crystallization. This transition transforms the unstable, high-energy amorphous solid into a stable crystalline solid with lower energy content, while the crystallization process itself remains relatively simple and can be integrated into existing synthesis workflows.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymorphic forms of NMNH disodium salt exhibit high purity, good stability, and low hygroscopicity, suitable for pharmaceutical, healthcare, and cosmetic applications, overcoming the limitations of amorphous solids.
Implementation Method 1
The synthesis process of NMNH in the market is still in the laboratory research and development stage, and it is not yet possible to realize industrial production. The main technical difficulties in the synthesis of NMNH are: 1) NMNH is a reduced form of NMN, which is easily oxidized by air; 2) In the laboratory, an aqueous solution with higher purity can be obtained only by preparative chromatography, and an amorphous solid can be obtained by freeze-drying.
Implementation Method 2
an amorphous solid can be obtained by freeze-drying. This method has no purification effect on the product, and the amorphous solid obtained by freeze-drying is foamy, has poor fluidity, is easy to absorb moisture and becomes oil, and degrades quickly
Data Source
AI summary
A polymorph of a reduced β-nicotinamide mononucleotide disodium salt, and a preparation method therefor and the use thereof as a pharmaceutical ingredient, a healthcare product ingredient, a cosmetic ingredient, or a food additives, and a preparation containing the salts are provided. A polymorph of NMNH disodium salt has excellent solubility, stability, flow performance, and hygroscopicity resistance. Its purification effects is better than that of amorphous forms.