NMR Treatment Parameter Tuning by Patient Chronotype

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Solution Overview

Problem

Existing nuclear magnetic resonance (NMR) treatment apparatuses lack precise parameter adjustment methods, particularly for low-field systems, which affects treatment efficacy and applicability across various indications.

Innovation Solution

The method involves determining the influence of NMR treatment on the cellular clock, specifically the circadian clock, and adjusting treatment parameters such as modulation frequency, field strength, and treatment intervals based on the user's chronotype, using sensors to measure physiological parameters like body temperature, heart rate, and skin resistance, and employing a microprocessor chip card for automated treatment sequences.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional NMR treatment apparatuses are used without precise parameter adjustment, then the device complexity is reduced and ease of operation is improved, but treatment efficacy and reliability deteriorate

Engineering Contradiction:

Improvetreatment efficacyVSAvoidparameter adjustment mechanism

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The system automatically determines chronotype using sensors (body temperature, heart rate, skin resistance) and self-adjusts treatment parameters without requiring manual calibration by operators, thereby improving treatment efficacy while avoiding increased operational complexity

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent adjusts key treatment parameters (modulation frequency, field strength, treatment intervals) based on determined chronotype parameters, optimizing treatment efficacy through dynamic parameter adaptation rather than fixed settings

Inventive Principle:

Principle #35Parameter changes

2Reliability

If treatment parameters are adjusted based on chronotype determination, then treatment effectiveness is improved, but measurement precision requirements and device complexity increase

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidphysiological parameter measurement

Core Design Contradiction:

ReliabilityVSMeasurement precision

Solution Approach 1:

The patent introduces chronotype determination as an intermediary step that translates complex physiological measurements into simplified treatment parameter adjustments, thereby improving treatment effectiveness while managing measurement complexity through intermediate processing

Inventive Principle:

Principle #24Intermediary (Mediator)

3Productivity

If automated treatment sequences using microprocessor chip cards are implemented, then productivity and treatment consistency are improved, but device complexity and initial setup time increase

Engineering Contradiction:

Improvetreatment delivery efficiencyVSAvoidautomated control system

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

Treatment sequences are pre-programmed into microprocessor chip cards before patient treatment, allowing automated execution of optimized protocols without requiring complex real-time decision-making systems during treatment delivery

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent uses chip cards as information carriers that store and transfer treatment sequence data, replacing complex software systems with simple, reliable physical media that can be easily exchanged and updated

Inventive Principle:

Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enhances treatment effectiveness by synchronizing the cellular circadian clock, improving outcomes for conditions like osteoarthritis and cellulite, and ensuring safe, optimized treatment delivery.

Implementation Method 1

Nuclear magnetic resonances can be generated in the treatment zone by appropriately tuning the frequency of the alternating field to the field strength of the perpendicular homogeneous field

Methodology Applied

Scientific EffectNuclear magnetic resonance: Resonance

Implementation Method 2

Nuclear magnetic resonances are generated cyclically in the treatment volume

Methodology Applied

Scientific EffectLarmor condition: Resonance

Implementation Method 3

Inhomogeneities of the basic static field B0 are compensated via the Adiabatic Fast Passage (AFP) path, which causes reversal of nuclear spin orientations

Methodology Applied

Scientific EffectAdiabatic Fast Passage:

Implementation Method 4

using sensors to measure physiological parameters like body temperature, heart rate, and skin resistance

Methodology Applied

Scientific EffectBody temperature measurement:

Implementation Method 5

using sensors to measure physiological parameters like body temperature, heart rate, and skin resistance

Methodology Applied

Scientific EffectHeart rate measurement:

Implementation Method 6

using sensors to measure physiological parameters like body temperature, heart rate, and skin resistance

Methodology Applied

Scientific EffectSkin resistance measurement: Electrical Resistance

Data Source

PatentUS12478795B2Method for adjusting an apparatus for the treatment using nuclear spin resonances

Publication Date: 2025.11.25 MEDTEC MEDIZINTECHNIK GMBH

AI summary

The invention relates to a method for adjusting an apparatus for treatment using nuclear magnetic resonances. The chronotype of the user is determined. The apparatus is adjusted on the basis of this determination.