Automated NMR Flow Cell Distribution Apparatus
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Solution Overview
Problem
Current monitoring devices for NMR spectroscopy lack automation and precise control over reaction parameters, leading to inefficient reaction control and potential changes in reaction conditions during sample transfer, with no comprehensive system control or temperature control along the entire flow path.
Innovation Solution
A compact monitoring device with an electrically controllable distribution apparatus and pump system, featuring a distribution vessel with integrated electrically controllable valves and pumps, allowing for automated and software-controlled reaction management, including temperature control of the entire flow path and essential components, reducing manual intervention and enhancing reproducibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If manual valve adjustment is used to control flow distribution, then device complexity is reduced, but automation capability and measurement precision deteriorate
Solution Approach 1:
The patent replaces manual mechanical valve adjustment with an electrically controllable valve system. The distribution apparatus includes at least one electrically controllable valve that can be remotely actuated to control the distribution of reaction fluid between the fast loop and slow loop, eliminating the need for manual mechanical adjustment while maintaining precise flow control.
2Adaptability or versatility
If multiple connection sites are used to connect coaxial lines, then fluid distribution flexibility is improved, but device complexity and reliability worsen
Solution Approach 1:
The patent merges the distribution function into a single integrated distribution apparatus that consolidates multiple connection sites into one location. The distribution apparatus serves as a central hub where reaction fluid is distributed to both fast loop and slow loop, reducing the number of separate connection sites needed while maintaining distribution flexibility through electrically controllable valves.
3Measurement precision
If manually adjustable reducing valve is used for flow volume control, then ease of operation is improved, but measurement precision and reliability of split ratio deteriorate
Solution Approach 1:
The patent replaces the manually adjustable reducing valve with an electrically controllable valve system. This substitution enables precise control of the split-flow ratio through electrical actuation, providing accurate and repeatable flow distribution while allowing remote adjustment without manual intervention at the valve location.
4Temperature
If reaction fluid is pumped over long distance between reactor and spectrometer, then spatial separation is maintained, but temperature stability and measurement precision worsen
Solution Approach 1:
The patent segments the transport system into two distinct loops: a fast loop for rapid fluid circulation and a slow loop for deliberate sample transfer to the spectrometer. This segmentation allows the fast loop to maintain temperature stability through continuous circulation while the slow loop handles the necessary long-distance transport, separating the temperature control function from the transport function.
5Adaptability or versatility
If fast loop and slow loop are implemented with four coaxial capillaries, then reaction monitoring capability is improved, but device complexity and ease of manufacture worsen
Solution Approach 1:
The patent segments the monitoring system into functionally independent fast loop and slow loop circuits that can be manufactured and assembled separately. The distribution apparatus serves as a central connection point where both loops are integrated, allowing each loop to be manufactured using simpler non-coaxial piping while maintaining the dual-loop monitoring capability through the unified distribution system.
Data Source
AI summary
A monitoring device is provided for analytical measurement of reaction fluid produced in a reaction vessel in a spectrometer with a monitoring cell. The distribution apparatus includes at least four supply and return lines that open into the distribution apparatus, wherein the distribution apparatus comprises a distribution device for distributing reaction fluid to the supply and return lines. The distribution apparatus comprises a distribution vessel in which the distribution device and an electrically controllable pump device for pumping of the reaction fluid are provided, wherein the distribution device comprises an electrically controllable valve device for distributing the reaction fluid to the lines that open into the distribution vessel. A control and regulating device for electrical control of the pump device and of the valve device is provided, wherein reaction control is prompt, automated, and optimized with respect to process parameters, and wherein temperature control may include the entire flow path.