NMR Relaxation Fingerprinting for Liquid Sample Identification
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Solution Overview
Problem
Current methods for species identification and quality detection of liquid-like samples, such as edible oils, milk, and gelatin, face challenges in accuracy, stability, and the need for destructive sample pretreatment, particularly when using traditional chromatography, mass spectrometry, and optical spectroscopy.
Innovation Solution
A method utilizing nuclear magnetic resonance (NMR) relaxation technology to amplify the differences in relaxation properties of liquid-like samples by measuring two-dimensional data sets containing 1H T1 and T2 relaxation properties, allowing for non-destructive species identification and quality detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional chromatography, mass spectrometry, and optical spectroscopy are used for species identification and quality detection, then measurement precision can be improved, but sample pretreatment is required which destroys the sample and reduces ease of operation
Solution Approach 1:
The patent replaces traditional mechanical/chemical separation methods (chromatography) and complex sample preparation procedures with nuclear magnetic resonance spectroscopy. The NMR method directly detects the molecular structure and composition of liquid samples without requiring physical separation or chemical treatment, thereby eliminating destructive sample pretreatment while maintaining species identification accuracy.
2Measurement precision
If traditional chromatography, mass spectrometry, and optical spectroscopy are used for species identification and quality detection, then measurement precision can be improved, but the detection process becomes time-consuming and reduces productivity
Solution Approach 1:
The patent replaces time-consuming chromatographic separation processes and multiple measurement steps with direct NMR spectroscopic detection. The NMR instrument can rapidly acquire spectral data from liquid samples, enabling quick species identification and quality assessment without the lengthy sample preparation and analysis procedures required by traditional methods.
3Measurement precision
If traditional chromatography, mass spectrometry, and optical spectroscopy are used for species identification and quality detection, then measurement precision can be improved, but device complexity increases due to requirement of large instruments
Solution Approach 1:
The patent replaces large, complex chromatography systems and mass spectrometers with nuclear magnetic resonance spectroscopy equipment. The NMR method achieves comparable or superior measurement precision for species identification while using a more compact instrument that does not require extensive sample preparation systems, thereby reducing overall device complexity.
4Ease of operation
If 1H T2 relaxation properties alone are measured using conventional methods, then ease of operation is improved, but measurement precision is insufficient to effectively distinguish different edible oils and adulteration
Solution Approach 1:
The patent transitions from measuring only one-dimensional T2 relaxation properties to measuring two-dimensional T1-T2 relaxation properties simultaneously. This dimensional expansion provides additional discriminatory information about the sample composition, enabling effective distinction between different edible oils and detection of adulteration while maintaining operational simplicity through automated measurement.
Solution Approach 2:
The patent changes the measurement parameters from single-parameter T2 relaxation to dual-parameter T1-T2 relaxation measurement. By incorporating T1 relaxation time in addition to T2, the method obtains more comprehensive molecular mobility and interaction information, significantly improving species identification accuracy while the automated protocol maintains ease of operation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves accurate and rapid species identification and quality detection of liquid-like samples without sample pretreatment, using low-field magnetic resonance instruments for on-site detection, and its digital fingerprint spectra facilitate authenticity judgments using artificial intelligence.
Implementation Method 1
a method of species identification and quality detection of liquid-like samples based on nuclear magnetic resonance relaxation technology
Implementation Method 2
measuring two-dimensional data sets containing 1H T1 and T2 relaxation properties
Data Source
AI summary
The present invention is directed to a method of species identification and quality detection of liquid-like samples based on nuclear magnetic resonance technology. In this invention, a two-dimensional relaxation signal containing the 1H T1 and T2 relaxation properties of liquid-like samples is obtained by applying a composite pulse sequence to samples, and from this a fingerprint spectrum is established. The fingerprint spectrum can be associated with the essential characteristics of the tested sample, thus can be used to distinguish a specific liquid-like sample from the others.