Halogenated Polymer Composite for NMR Susceptibility Matching
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Solution Overview
Problem
High-field nuclear magnetic resonance (NMR) applications face challenges in maintaining magnetic field homogeneity due to materials used in the sensitive volume, requiring frequent shimming and increased sample volume for susceptibility matching, which complicates handling and increases costs.
Innovation Solution
A compound comprising a halogenated or perhalogenated polymer combined with inorganic or metallo-organic particulate diamagnetic or paramagnetic materials is used to match the magnetic volume susceptibility of the sample, allowing for a mechanically stable, machinable, and cost-effective material that minimizes magnetic field distortions and reduces the need for shimming.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional materials (glass, standard polymers) are used in the sensitive volume of NMR devices, then mechanical stability and ease of manufacture are achieved, but magnetic field homogeneity deteriorates due to susceptibility mismatches requiring frequent shimming
Solution Approach 1:
The patent changes the magnetic susceptibility parameter of the construction material by incorporating paramagnetic and/or diamagnetic particles into the polymer matrix. This allows the material's magnetic properties to be tuned to match the sample's susceptibility, thereby maintaining magnetic field homogeneity without requiring additional shimming operations.
Solution Approach 2:
The patent uses composite materials consisting of a polymer base material combined with paramagnetic and/or diamagnetic particles. This composite structure enables the construction material to achieve magnetic susceptibility values that match the sample, resolving the contradiction between mechanical stability and magnetic field homogeneity.
2Reliability
If susceptibility matching is achieved using conventional methods, then magnetic field homogeneity is improved, but sample volume must be increased to compensate for signal loss
Solution Approach 1:
By changing the magnetic susceptibility parameter of the construction material to match the sample, the patent eliminates the need to increase sample volume for susceptibility matching. The material itself becomes magnetically transparent, allowing smaller sample volumes to be used while maintaining field homogeneity and signal quality.
3Reliability
If paramagnetic and diamagnetic particles are incorporated into polymer materials, then magnetic susceptibility matching is achieved, but manufacturing complexity increases
Solution Approach 1:
The patent develops composite materials where paramagnetic and diamagnetic particles are incorporated into a polymer matrix. While this increases material complexity, the use of standard polymer bases and discrete particle additives maintains relative ease of manufacture through conventional mixing and molding techniques.
Solution Approach 2:
The patent applies local quality by adding magnetic particles only to the specific regions where susceptibility matching is needed, rather than requiring uniform complexity throughout the entire device structure. This allows targeted magnetic property adjustment without proportionally increasing overall manufacturing complexity.
4Ease of operation
If standard polymer materials are used for sample holders, then ease of operation and cost-effectiveness are achieved, but magnetic field distortions increase
Solution Approach 1:
The patent changes the magnetic susceptibility parameter of the polymer material used for sample holders and construction elements. By incorporating paramagnetic and diamagnetic particles, the material's magnetic properties are adjusted to match the sample, eliminating magnetic field distortions while maintaining the ease of operation and cost-effectiveness of polymer-based components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compound ensures high signal-to-noise ratios by maintaining magnetic field homogeneity, reducing sample volume requirements, and simplifying handling and manufacturing processes, while being suitable for high-resolution NMR applications up to 27 T without the need for extensive adaptation of device settings.
Implementation Method 1
A compound comprising a halogenated or perhalogenated polymer combined with inorganic or metallo-organic particulate diamagnetic or paramagnetic materials is used to match the magnetic volume susceptibility of the sample
Implementation Method 2
inorganic or metallo-organic particulate diamagnetic or paramagnetic materials
Implementation Method 3
inorganic or metallo-organic particulate diamagnetic or paramagnetic materials
Data Source
AI summary
A compound consisting of the following components:(A) 40-99.99 weight percent of at least one thermoplastic or thermoset polymer material selected as a halogenated or perhalogenated polymer;(B) 0.01-60 weight percent of at least one inorganic particulate diamagnetic or paramagnetic material;(C) 0-39.99 weight percent of at least one additive different from (B);is proposed as a construction material in the detection-relevant spatial area (9) of a nuclear magnetic resonance device with a static magnetic field of at least 1 Tesla, and furthermore corresponding constructional elements, in particular sample holders, our proposed as well as method of manufacturing such constructional elements and uses of such constructional elements.