NO Delivery Device Calibration Without Certified Gas Standards
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Solution Overview
Problem
Existing calibration methods for NO and NO2 sensors in clinical settings require complex and costly high-pressure gas cylinders with certified standards, which are difficult to maintain and prone to degradation, especially at low ppm concentrations, making accurate calibration challenging and time-consuming.
Innovation Solution
A method that uses unknown concentration gas samples to determine the rate of NO loss and NO2 formation over time, eliminating the need for precise calibration standards by leveraging well-documented kinetic reactions, allowing for accurate calibration through measuring the rate of change in NO and NO2 signals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If high-pressure gas cylinders with certified standards are used for calibration, then measurement precision is improved, but device complexity and ease of operation deteriorate due to maintenance difficulties and degradation issues
Solution Approach 1:
The invention extracts the essential calibration function from complex high-pressure gas cylinder systems and implements it using simple syringes and kinetic reaction principles. The calibration process is reduced to basic components: a syringe, known reactant concentration, and timing, eliminating the need for complex certified gas standards while maintaining measurement precision.
Solution Approach 2:
The invention replaces expensive, maintenance-intensive high-pressure gas cylinders with inexpensive, disposable syringes. The syringes are simple, cheap objects that eliminate the complexity of maintaining certified gas standards, while the kinetic reaction method provides a reliable way to generate known concentrations on-demand without requiring long-lived storage standards.
2Measurement precision
If high-pressure gas cylinders with certified standards are used for calibration, then measurement precision is improved, but ease of operation worsens due to time-consuming procedures
Solution Approach 1:
The invention performs preliminary action by pre-calculating the required reactant volume based on desired NO concentration and container volume using the known kinetic rate constant. This allows the calibration process to proceed directly to the reaction and measurement steps without time-consuming setup or verification of gas standard concentrations, significantly reducing calibration time while maintaining precision.
3Manufacturing precision
If low ppm gas standards are stored for long periods, then manufacturing precision is improved, but reliability deteriorates due to sticking and degradation on container walls
Solution Approach 1:
The invention replaces static, long-term storage of gas standards with a dynamic, on-demand generation approach. Instead of storing low ppm standards that degrade over time, the system dynamically generates known concentrations by mixing known volumes of high-concentration NO with air in controlled containers. This dynamic approach eliminates degradation issues while maintaining manufacturing precision through calculated mixing ratios.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides a reliable and efficient calibration process that ensures high accuracy and reduces the need for specialized gas cylinders, ensuring precise NO and NO2 sensor calibration without the limitations of traditional methods.
Implementation Method 1
leveraging well-documented kinetic reactions
Implementation Method 2
the NO, in the presence of O2, can be oxidized to nitrogen dioxide (NO2)
Data Source
AI summary
A device and method for calibrating a NO delivery device using NO and NO2 measurements, without using a known standard.