Nitric Oxide Eluting Polymer for Skin Irritation Reduction
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Solution Overview
Problem
Current cosmetic treatments for issues caused by chronological age, environmental factors, skin physiological changes, psoriasis, dermatitis, and viral/bacteriological attacks are limited by skin irritation, high concentration requirements, pH incompatibility, and resistance development, lacking a method to simultaneously treat and prevent these conditions effectively.
Innovation Solution
A device and method utilizing a nitric oxide (NO) eluting polymer, such as L-PEI diazeniumdiolate, that releases NO to target affected areas, increasing blood perfusion and providing anti-viral and anti-microbial effects without causing significant skin irritation or resistance, using polymers like polyalkyleneimines and microencapsulated proton donors to control NO release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic treatments are applied to treat skin disorders, then treatment effect is achieved, but skin irritation and resistance development occur
Solution Approach 1:
The patent changes the chemical parameter by using nitric oxide (NO) as the active ingredient instead of conventional cosmetic agents. NO is applied at controlled low concentrations (0.001-5000 ppm) to achieve therapeutic effects without causing skin irritation or resistance, fundamentally altering the chemical composition parameter of the treatment
Solution Approach 2:
The patent uses polymers as intermediary carriers to deliver nitric oxide to the skin. These polymer intermediaries control the release of NO, ensuring it reaches the target tissues in controlled amounts while preventing direct contact irritation and maintaining stable delivery to affected areas
2Reliability
If high concentrations of active ingredients are used to achieve treatment效果, then treatment effectiveness is improved, but skin toxicity and irritation increase
Solution Approach 1:
The patent implements periodic or controlled release of nitric oxide through polymer carriers rather than continuous high-concentration application. The NO is released in controlled pulses or sustained low concentrations over time, maintaining therapeutic effectiveness while avoiding the toxic effects associated with high concentrated applications
Solution Approach 2:
The patent fundamentally changes the concentration parameter from high concentrations (conventional treatments) to low concentrations (0.001-5000 ppm for NO). This parameter change, combined with controlled release mechanisms, achieves treatment effectiveness without the skin toxicity inherent in high-concentration formulations
3Duration of action of stationary object
If conventional treatments are applied repeatedly to maintain effect, then sustained treatment benefit is achieved, but resistance development occurs
Solution Approach 1:
The patent uses polymer intermediaries to deliver nitric oxide, which prevents direct skin contact and reduces the development of resistance. The polymer carrier mediates the delivery process, allowing sustained treatment benefit while the indirect delivery mechanism prevents the skin from developing tolerance or resistance to the active ingredient
4Adaptability or versatility
If multiple cosmetic treatments are used to address different skin conditions, then comprehensive coverage is achieved, but device complexity and treatment regimen complexity increase
Solution Approach 1:
The patent applies nitric oxide as a universal active ingredient that can treat multiple skin conditions (psoriasis, dermatitis, viral infections, bacterial infections, and general skin disorders) with a single treatment approach. This multi-functional capability eliminates the need for multiple different treatments and simplifies the overall treatment regimen while maintaining comprehensive coverage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The NO eluting polymer device effectively treats and prevents cosmetic disorders by enhancing blood perfusion and providing anti-viral and anti-microbial effects, reducing skin irritation and resistance, while allowing for controlled NO release profiles.
Implementation Method 1
a nitric oxide (NO) eluting polymer arranged to contact the area to be treated, such that a cosmetic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said area
Data Source
AI summary
A cosmetic treatment device includes a nitric oxide (NO) eluting polymer, a carrier, and a proton donor enclosed in a container that keeps the proton donor separate from the nitric oxide eluting polymer until the device is used. When the container is opened, proton donor contacts the polymer, causing the elution of nitric oxide from the polymer.