Nitric Oxide-Generating Adherent Coating for Biomedical Devices
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Solution Overview
Problem
Current NO-releasing materials for biomedical devices face challenges such as short half-life and uncertain safety doses, leading to inadequate long-term NO release, which limits their commercial use in applications like vascular stents and artificial blood vessels.
Innovation Solution
A nitric oxide-generating adherent coating is developed using polyphenol compounds, organic selenium or sulfur compounds, and soluble copper salts, which form a stable and controllable NO release coating through chemical coupling and molecular self-assembly, allowing firm adhesion to various materials and prolonged NO release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional NO-releasing materials are used, then initial NO release is achieved, but the release duration is too short for long-term implantation
Solution Approach 1:
The patent applies preliminary action by pre-coating the medical device surface with GPx-like catalytically active molecules before implantation. This pre-prepared coating system is designed to continuously catalyze RSNO decomposition into NO over extended periods, solving the short duration problem of conventional NO-releasing materials while maintaining long-term stability through the stable enzyme-matrix structure.
Solution Approach 2:
The patent employs composite materials by creating a coating system that integrates GPx-like catalytically active molecules (organic selenium or sulfur compounds) within a stable matrix material. This composite structure combines the catalytic activity for continuous NO generation with the structural stability needed for long-term implantation, resolving both duration and reliability requirements.
2Quantity of substance
If GPx-like catalytically active molecules are grafted onto material surface, then NO generation capability is achieved, but grafting amount is insufficient due to lack of functional groups
Solution Approach 1:
The patent applies parameter changes by modifying the surface properties of the medical device through a coating process that enables high-density grafting of GPx-like molecules. By changing the surface parameters (creating a coating layer with appropriate physical and chemical properties), the system achieves sufficient grafting amounts without requiring complex pre-functionalization of the base material, thus solving both the quantity and manufacturing ease problems.
3Duration of action of stationary object
If NO-releasing materials are used for long-term implantation, then continuous NO delivery is required, but current materials have uncertain safety doses limiting commercial use
Solution Approach 1:
The patent applies self-service by creating a coating system that automatically regulates NO production through the catalytic decomposition of endogenous RSNO substrates present in blood. The GPx-like catalytically active molecules continuously convert available RSNO into NO without requiring external dosing or complex delivery mechanisms, providing long-term safe NO delivery that adapts to physiological conditions and eliminates uncertain safety dose issues.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coating ensures stable, long-term, and controllable NO release, enhancing blood compatibility, antimicrobial properties, and osteoinductive effects, suitable for biomedical devices and materials, including vascular stents and dental implants.
Implementation Method 1
Organic selenium compounds such as selenocystamine (SeCA) and 3,3'-diselenodipropionic acid (SeDPA), and organic sulfur compounds such as cystamine and cysteine have GPx-like activity to catalyze RSNO decomposition for NO production
Implementation Method 2
A nitric oxide-generating adherent coating is developed using polyphenol compounds, organic selenium or sulfur compounds, and soluble copper salts, which form a stable and controllable NO release coating through chemical coupling and molecular self-assembly
Implementation Method 3
A nitric oxide-generating adherent coating is developed using polyphenol compounds, organic selenium or sulfur compounds, and soluble copper salts, which form a stable and controllable NO release coating through chemical coupling and molecular self-assembly
Implementation Method 4
A nitric oxide-generating adherent coating is developed using polyphenol compounds, organic selenium or sulfur compounds, and soluble copper salts, which form a stable and controllable NO release coating through chemical coupling and molecular self-assembly, allowing firm adhesion to various materials
Data Source
AI summary
Disclosed is a method for preparing a nitric oxide-generating adherent coating, comprising: preparing a buffer solution containing polyphenol compounds, organic selenium or sulfur compounds and soluble copper salts; then contacting a base material with the solution, and washing and drying to obtain a target product. The nitric oxide-generating material prepared by the method can be used for any medical device, such as an intravascular stent, or materials and any complex-shaped base material, and has the capability of scavenging free radicals and catalyzing RSNO to produce nitrogen monoxide, and also has a response function of reduced glutathione (GSH), an antimicrobial function and all the physiological functions possessed by nitrogen monoxide.