NO-Infused Liquid Composition for Nitric Oxide Stability

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Nitric oxide (NO) is notoriously unstable in water and other aqueous solutions, rapidly oxidizing to NO2 and losing its effectiveness within minutes due to oxygen presence, making it challenging to create stable NO solutions for practical applications.

Innovation Solution

Infusing nitric oxide gas (NO) and hydrogen gas (H2) into liquids, with concentrations of at least 1 ppm and 100 ppb respectively, to stabilize NO and maintain its concentration for extended periods, even in the presence of oxygen.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If nitric oxide gas is infused into water or aqueous solutions, then the solution contains NO for potential applications, but the NO rapidly oxidizes to NO2 and loses stability within minutes due to oxygen presence

Engineering Contradiction:

ImproveNO concentrationVSAvoidNO stability

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent uses an oxygen-scavenging system comprising reducing agents (such as glucose, ascorbic acid, or sulfite) as intermediary substances that react with dissolved oxygen in the aqueous solution, thereby protecting NO from oxidation. These reducing agents act as mediators between the NO and oxygen, consuming the oxygen through chemical reduction reactions and preventing the harmful oxidation of NO to NO2.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates an oxygen-free or low-oxygen environment in the aqueous solution by introducing oxygen-scavenging reducing agents that continuously consume dissolved oxygen. This establishes an inert chemical environment where NO can remain stable without oxidizing, effectively replacing the need for physical inert gas atmospheres with chemical oxygen removal.

Inventive Principle:

Principle #39Inert atmosphere (Inert environment)

2Stability of the object's composition

If conventional methods are used to prepare saturated NO solutions by excluding O2 through hermetic sealing and inert gas atmospheres, then NO stability is improved, but the process complexity and cost increase significantly

Engineering Contradiction:

ImproveNO stabilityVSAvoidpreparation process complexity

Core Design Contradiction:

Stability of the object's compositionVSDevice complexity

Solution Approach 1:

Instead of using complex hermetic sealing systems and inert gas purification apparatus, the patent introduces simple chemical reducing agents as intermediaries that automatically scavenged oxygen through chemical reactions. This chemical approach replaces complex physical isolation systems with straightforward chemical addition, dramatically simplifying the preparation process.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent employs inexpensive, readily available reducing agents (such as glucose, ascorbic acid, or sulfite) that can be simply added to the solution to scavenge oxygen. These cheap chemical substances replace expensive inert gases and complex hermetic equipment, providing a cost-effective and simple solution for NO stabilization.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Reliability

If NO solution is administered to subjects, then NO benefits can be provided, but the limited NO rapidly disappears in the oxygen-rich environment of the mouth and stomach, becoming unavailable for physiological effects

Engineering Contradiction:

ImproveNO effectivenessVSAvoidNO half-life in biological fluids

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent incorporates oxygen-scavenging reducing agents in the NO-containing aqueous composition that protect NO from oxidation during administration through the oxygen-rich environment of the mouth and gastrointestinal tract. These reducing agents act as chemical protectors, consuming oxygen and maintaining NO in its reduced, active form until it reaches the target physiological site, thereby extending its effective duration and reliability.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The NO+H2 solution remains stable with minimal degradation, allowing for effective administration and utilization of NO's benefits, such as treating various health conditions and enhancing athletic performance.

Implementation Method 1

the liquid is contacted with hydrogen gas to reduce the concentration of dissolved oxygen in the liquid to less than 1 ppm

Methodology Applied

Scientific EffectOxygen scavenging by hydrogen: Redox Reactions

Implementation Method 2

wherein the NO and the H2 are diffused in the liquid

Methodology Applied

Scientific EffectGas diffusion: Diffusion

Implementation Method 3

the NO and the H2 in the composition are dissolved in the liquid

Methodology Applied

Scientific EffectGas dissolution: Absorption (physical)

Data Source

PatentUS20260027149A1Nitric oxide gas-infused liquids and related methods

Publication Date: 2026.01.29 THERMOLIFE INTERNATIONAL LLC

AI summary

A novel method of producing an NO+H2 solution is disclosed as well as liquid compositions comprising stable and high concentrations of NO and H2.