NO-Sensitive Hydrogel for Local Nitric Oxide Scavenging
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Solution Overview
Problem
Existing technologies fail to effectively capture and eliminate overproduced nitric oxide locally and selectively, leading to rapid diffusion and systemic toxicity, which complicates the treatment of inflammatory diseases like rheumatoid arthritis.
Innovation Solution
A nitric oxide-sensitive hydrogel is formed in-situ through a click chemical reaction using compounds represented by Formulae 1 to 3, which captures and eliminates overproduced nitric oxide, and releases a drug locally and selectively based on nitric oxide concentration, utilizing a crosslinking agent, micelle structure, and hyaluronic acid polymer for targeted treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If nanometer-scale technologies are used to capture nitric oxide, then ease of injection is improved, but rapid diffusion and removal to organs other than the injection site occurs causing systemic toxicity
Solution Approach 1:
The patent creates a hydrogel with localized properties at the injection site that selectively captures nitric oxide. The hydrogel contains functional groups (such as diazeniumdiolates) that have high affinity for nitric oxide, creating a localized zone of nitric oxide scavenging that prevents systemic distribution while maintaining ease of injection
2Quantity of substance
If nitric oxide is removed non-specifically, then nitric oxide levels are reduced, but numerous side effects occur including systemic toxicity
Solution Approach 1:
The hydrogel acts as an intermediary substance that selectively interacts with nitric oxide through specific chemical functional groups. These groups (such as diazeniumdiolates) serve as mediators that bind nitric oxide with high selectivity, allowing removal of excess nitric oxide while preserving normal physiological levels and avoiding non-specific side effects
3Speed
If nitric oxide is captured rapidly, then nitric oxide levels are reduced quickly, but the duration of action is insufficient for chronic inflammatory diseases
Solution Approach 1:
The hydrogel provides continuous nitric oxide capture capability through its stable gel structure and persistent functional groups. The hydrogel matrix maintains a reservoir of nitric oxide-binding sites that continuously scaveng nitric oxide over extended periods, ensuring sustained therapeutic action for chronic inflammatory diseases rather than transient effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel effectively scavenges nitric oxide, reduces pro-inflammatory cytokines, and delivers therapeutic agents to the disease site, providing localized treatment with minimal invasiveness and avoiding systemic toxicity, thus alleviating inflammatory diseases.
Implementation Method 1
can effectively collect and scavenge nitric oxide overexpressed in the target site
Implementation Method 2
a drug loaded in the hydrogel can be locally and sensitively released to a target site to be treated
Implementation Method 3
The hydrogel is formed through in-situ hybridization in a target site by means of a click chemical reaction
Data Source
AI summary
The present disclosure relates to a nitric oxide-sensitive hydrogel. The hydrogel is formed through in-situ hybridization in a target site by means of a click chemical reaction and is prepared using a nitric oxide-sensitive crosslinker. The hydrogel can effectively collect and scavenge nitric oxide overexpressed in the target site, and a drug loaded in the hydrogel can be locally and sensitively released to a target site to be treated. Therefore, the hydrogel can be effectively used to prevent and treat inflammatory disease caused by the overexpression of nitric oxide.