Non-emulsion topical composition for skin irritation
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Solution Overview
Problem
Topical products often cause irritation to the skin or mucous membranes due to preservatives, detergents, or drugs, leading to inflammation and discomfort, and existing methods struggle to effectively mitigate these effects without compromising the product's functionality.
Innovation Solution
A combination of xylitol, myoinositol, or mannitol with glycerol and/or urea, along with a surface active agent, is used in topical compositions to reduce irritation and enhance spread and viscosity, creating a non-irritant formulation for mucous and skin cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If preservatives, detergents or drugs are used in topical products, then the product functionality is maintained, but irritation and cell damage occur
Solution Approach 1:
The patent introduces a combination of polyols (xylitol, myoinositol, or mannitol) with glycerol and/or urea as intermediary substances that mediate between the irritating topical product ingredients and the skin/mucous cells. These polyols act as protective agents that reduce the harmful effects of preservatives, detergents, and drugs while allowing the products to maintain their intended functionality.
Solution Approach 2:
The patent converts the harmful irritation caused by topical product ingredients into a beneficial effect by using polyols to trigger a protective cellular response. The polyols induce cells to activate defense mechanisms that actually protect against the irritating substances, thereby converting the harmful irritation into a beneficial protective effect.
2Object-affected harmful factors
If polyols are used to reduce irritation, then cell damage is reduced, but product spread and viscosity may be compromised
Solution Approach 1:
The patent optimizes the concentration parameters of polyols (specifically 1.5-5.5% xylitol, myoinositol or mannitol combined with 0.9-2.0% glycerol) to achieve the desired balance between cell protection and product spreadability. By carefully controlling these concentration parameters, the formulation maintains both protective efficacy and appropriate rheological properties for easy application.
3Object-affected harmful factors
If higher concentrations of protective agents are used, then irritation is reduced, but product complexity increases
Solution Approach 1:
The patent uses a composite formulation approach by combining multiple polyols (xylitol, myoinositol, or mannitol with glycerol and/or urea) in specific ratios. This composite approach provides synergistic protection against irritation while maintaining a relatively simple formulation structure that does not significantly increase product complexity.
Data Source
AI summary
The present invention provides a method of treatment of irritation of skin or mucous cells. The method comprises applying topically a composition comprising a combination of: xylitol, myonisotiol or mannitol or any combination of these; glycerol and/or urea; water; in the absence of any oil in water or wax in water emulsion.