Non-Matrix Titration Package Asymmetry for Dosing Accuracy

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Solution Overview

Problem

Existing titration packages with matrix-like arrangements can lead to accidental miss-dosing due to their symmetric geometry, which can be confusing for patients with impaired senses or cognitive issues, especially when different dosages are present in adjacent rows or columns.

Innovation Solution

A titration package with non-matrix-like arrangement of sets, where each set comprises three individually addressable regions, with sets being physically separated and differentiated in position, and distances between adjacent regions within a set are significantly smaller than between regions of different sets, reducing the likelihood of accidental switching between dosages.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If a matrix-like arrangement is used in titration packages, then the structure is simple and systematic, but it leads to accidental miss-dosing due to symmetric geometry being confusing for patients with impaired senses or cognitive issues

Engineering Contradiction:
Improveease of use for patients with impaired sensesVSAvoidaccuracy of dosing
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The patent applies asymmetry by arranging sets of pharmaceutical compositions in a non-matrix-like configuration where sets are physically separated and differentiated in position. The distances between adjacent regions within a set are significantly smaller than between regions of different sets, creating an asymmetric layout that reduces confusion for patients with impaired senses or cognitive issues while maintaining dosing accuracy

Inventive Principle:
Principle #4Asymmetry

2Area of stationary object

If different dosages are placed in adjacent rows or columns of a matrix arrangement, then the package is compact and systematic, but it increases the risk of accidental switching between dosages

Engineering Contradiction:
Improvepackage sizeVSAvoiddosage accuracy
Core Design Contradiction:
Area of stationary objectVSReliability

Solution Approach 1:

The patent segments the package into distinct sets, each containing pharmaceutical compositions of a specific dosage. These sets are physically separated and differentiated in position, with clear spatial separation between sets containing different dosages. This segmentation prevents accidental switching while maintaining a compact overall package structure

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent uses asymmetric positioning where sets with different dosages are placed at distinct locations with significant distance separation. The non-uniform spacing between regions creates clear visual and spatial differentiation between dosage groups, reducing the risk of accidental switching while keeping the package compact

Inventive Principle:
Principle #4Asymmetry

Data Source

PatentUS9314401B2Titration package
Publication Date: 2016.04.19 MERZ PHARMA GMBH & CO KGAA
  • US9314401B2 patent drawing
  • US9314401B2 patent drawing
  • US9314401B2 patent drawing

AI summary

The present invention relates to a titration package for providing at least one pharmaceutical composition in at least two different dosages. The titration package comprises at least two sets. Each set comprises at least three individually addressable regions. Each addressable region preferably comprises or is represented by a pharmaceutical composition, preferably a tablet. The dosage of the pharmaceutical composition is the same within each of the at least two sets (“common dosage”), while the dosages of the pharmaceutical compositions are different for one of the at least two sets compared to at least one other of the at least two sets. The arrangement of the at least two sets is not a matrix-like arrangement.