Non-resorbable Bone Allografts via Thermal Processing
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Solution Overview
Problem
Current bone grafting materials, such as xenografts and allografts, have limitations in biocompatibility and osteoconductivity, requiring the use of multiple materials for different clinical indications, which increases costs and complexity.
Innovation Solution
A method for producing non-resorbable bone allografts through a process involving excision, freeze-drying, demineralization, preservation, and thermal processing at temperatures greater than 300 degrees Celsius, enhancing osteoconductivity and biocompatibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If thermal processing is applied to xenografts to achieve non-resorbable properties, then non-resorbability is improved, but biocompatibility deteriorates due to complete deproteinization
Solution Approach 1:
The patent applies thermal processing at controlled temperatures (300-500°C) for specific durations to achieve the desired balance between non-resorbability and biocompatibility. This parameter change approach allows modification of the bone graft's thermal properties to create a non-resorbable allograft that retains some biological activity, resolving the contradiction between stability and reliability.
2Adaptability or versatility
If multiple bone grafting materials are used to fulfill different clinical functions, then adaptability is improved, but device complexity and cost increase
Solution Approach 1:
The patent creates a universal non-resorbable bone graft material that can serve multiple clinical indications previously requiring different materials. By achieving non-resorbability through controlled thermal processing while maintaining biocompatibility, the invention provides a single material that can replace both resorbable allografts and xenografts for various applications, reducing the number of materials needed.
3Stability of the object's composition
If thermal processing is applied to allografts to achieve non-resorbable properties, then non-resorbability is improved, but osteoinductivity deteriorates due to denaturing of growth factors
Solution Approach 1:
The patent applies partial thermal processing at moderate temperatures (300-500°C) rather than complete thermal sterilization. This partial action approach is sufficient to achieve non-resorbability while preserving the growth factors and proteins necessary for osteoinductivity, thereby resolving the contradiction between stability and reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The produced non-resorbable allografts exhibit improved osteoconductivity and biocompatibility compared to xenografts, allowing for enhanced bone regeneration in dental and medical applications while reducing the need for multiple grafting materials.
Implementation Method 1
freeze-drying the bone allografts
Implementation Method 2
thermal processing of the bone allografts at a temperature greater than about 300 degrees Celsius
Data Source
AI summary
A method for producing non-resorbable bone allografts having improved osteoconductivity and biocompatibility in regenerative dental and medical applications as compared with non-resorbable xenografts. The method comprises excising one or more bone allografts from a donor's body; freeze-drying the bone allografts; demineralizing the freeze-dried bone allografts; preserving and sterilizing the bone allografts; and thermal processing of the bone allografts at a temperature greater than about 300 degrees Celsius.