Non-invasive Raman Probe for Rapid Blood Glucose Measurement
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Solution Overview
Problem
Non-invasive methods for measuring bio-fluid components like blood glucose using Raman spectroscopy face challenges with low signal intensity, leading to prolonged measurement times and potential light-induced burns, while invasive methods are painful and costly.
Innovation Solution
A non-invasive probe system that irradiates light onto multiple measuring points, using a light splitting unit, condensing unit, and spectrometer to obtain and process Raman spectra, maintaining safe light intensity and achieving rapid measurement through simultaneous irradiation and tissue modulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the intensity of light incident into the human body is increased to solve the problem of small signal intensity in Raman spectrum, then the measurement reliability is improved, but the light intensity may cause a burn
Solution Approach 1:
The patent divides the single light beam into multiple separate light beams using a light splitting unit. Each light beam is directed to a different measuring point on the body surface. This segmentation allows the system to obtain multiple Raman spectra simultaneously without requiring each individual beam to have high intensity, thus avoiding burn risks while maintaining measurement reliability through cumulative signal acquisition from multiple points.
2Reliability
If light is irradiated multiple times to measure blood glucose concentration using Raman spectroscopy, then the measurement reliability is improved, but the measurement time becomes three minutes or longer
Solution Approach 1:
The patent pre-configures multiple measuring points on the body surface before measurement begins. The light splitting unit is set up to simultaneously direct multiple light beams to these pre-positioned measuring points. This preliminary arrangement enables parallel acquisition of multiple Raman spectra in a single measurement cycle, reducing measurement time from three minutes or longer to a much shorter duration while maintaining reliability through multi-point data collection.
3Reliability
If an invasive method is used to measure blood glucose concentration by directly collecting blood, then the measurement reliability is improved, but pain and possible infection occur
Solution Approach 1:
The patent uses Raman spectroscopy as an intermediary measurement technique that detects blood glucose concentration indirectly through light interaction with molecules in the body's tissues, rather than requiring direct blood collection. The light beams pass through the body's tissues and interact with glucose molecules, allowing non-invasive measurement of glucose concentration without piercing the skin or collecting blood, thus eliminating pain and infection risks while maintaining measurement reliability.
4Reliability
If an invasive method is used to measure blood glucose concentration by directly collecting blood, then the measurement reliability is improved, but economic burden increases due to the need for supplies such as strip and syringe
Solution Approach 1:
The patent replaces the mechanical invasive system (syringe, test strip, manual blood collection) with an optical measurement system using light beams and Raman spectroscopy. Instead of requiring physical blood collection and chemical test strips, the system uses non-invasive optical detection to measure glucose concentration, eliminating the need for disposable medical supplies and reducing economic burden while maintaining measurement reliability through sophisticated optical sensing and signal processing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables reliable and rapid measurement of bio-fluid components with reduced light intensity, preventing burns and minimizing invasive procedure drawbacks.
Implementation Method 1
a ray of light having a certain wavelength is focused and irradiated onto a certain portion of the body, a capillary vessel for example, and the concentration of blood glucose is measured using a Raman spectrum, the wavelength of which is changed by glucose molecules
Implementation Method 2
an output light transferring unit which transfers a plurality of output lights, which correspond to the number of the measuring points and are obtained by irradiating the plurality of living body incident lights, to a spectrometer that classifies the output lights by a wavelength unit
Data Source
AI summary
A non-invasive probe for measuring body components, and a non-invasive body component measurement system including the non-invasive probe is provided. The non-invasive probe includes an input light transferring unit for transferring an input light emitted from a light source; a light splitting unit for splitting the input light into a plurality of living body incident lights; a light condensing unit for condensing the plurality of living body incident lights, so that the plurality of living body incident lights can be irradiated onto a plurality of measuring points, each measuring point corresponding to one of the plurality of living body incident lights; and an output light transferring unit for transferring a plurality of output lights, which each correspond to the one of the plurality of measuring points and, which are obtained by irradiating the plurality of living body incident lights, to a spectrometer that classifies the output lights by wavelength.