Non-Reflective Beads for Biologic Fluid Analysis Chamber
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Solution Overview
Problem
Existing biologic fluid analysis techniques face challenges such as reliance on technician skill, sample dilution, and light reflection issues during photometric imaging, which affect the accuracy and reliability of results.
Innovation Solution
A biologic fluid analysis chamber with beads configured to absorb or be non-reflective at specific wavelengths, minimizing light interference and allowing for accurate photometric analysis without the need for sample dilution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If beads are used in the analysis chamber, then sample handling is simplified and cell integrity is maintained, but light reflection from beads interferes with photometric analysis accuracy
Solution Approach 1:
The patent applies color changes by selecting beads with specific optical properties that absorb rather than reflect incident light. The beads are chosen to have colors or coatings that minimize light reflection across the spectral range used for photometric analysis, thereby eliminating the harmful reflective effect while preserving the beneficial sample handling properties of beads
2Productivity
If flow cytometry is used to analyze constituents, then analysis can be performed, but sample dilution and complex fluid flow handling apparatus are required
Solution Approach 1:
The patent extracts and eliminates the need for complex fluid flow handling apparatus by designing a static analysis chamber where samples are analyzed in place. The chamber allows direct imaging of undiluted samples without requiring pumping, flow control, or dilution systems, thereby removing the harmful complexity while preserving analytical capability
Solution Approach 2:
The analysis chamber is designed to be self-sufficient, requiring no external fluid handling systems. The chamber structure itself enables sample containment and optical access, allowing the system to perform analysis without relying on complex external apparatus for fluid delivery, flow control, or sample preparation
3Device complexity
If manual smear evaluation is used, then equipment requirements are minimal, but results depend heavily on technician experience and technique
Solution Approach 1:
The patent replaces the manual mechanical process of smear preparation with an automated optical imaging system. Instead of requiring technicians to manually create and evaluate smears, the system uses a controlled analysis chamber with standardized lighting and imaging to automatically capture sample images, thereby eliminating the harmful dependency on technician skill while maintaining simple equipment requirements
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables reliable and accurate photometric analysis of biologic fluids by reducing light reflection from beads, improving data integrity and reducing the dependency on technician skill, while maintaining the sample in an undiluted state.
Implementation Method 1
the plurality of beads are configured to absorb the incident light in an amount great enough such that any light incident to the beads that is not absorbed does not appreciably interfere with a photometric analysis of the biologic fluid
Data Source
AI summary
A biological fluid sample analysis chamber and a method for analyzing a biological fluid sample is provided. The chamber includes a first chamber panel, a second chamber panel, and a plurality of beads disposed between the first chamber panel and the second chamber panel, which beads are configured to not reflect light incident to the beads in an amount that appreciably interferes with a photometric analysis of the biologic fluid.