Nonwoven Antimicrobial Wipe for Octenidine Release and Stability
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Solution Overview
Problem
Existing antimicrobial wipes are not suitable for antiseptic solutions other than chlorhexidine gluconate, and there is a need for a more potent antiseptic solution that effectively releases antiseptic agents when applied to skin.
Innovation Solution
A non-woven wipe comprising a blend of polyester fibers with an antiseptic solution containing a bis-(dihydropyridinyl)-decane derivative, such as octenidine dihydrochloride, and additional components like glycerin and surfactants, which is sterilized by heat to maintain antimicrobial efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a non-woven washcloth is specially designed for non-alcoholic CHG solution, then absorbing and holding properties for CHG are improved, but suitability for other antiseptic solutions is lost
Solution Approach 1:
The washcloth is designed with a universal fiber composition (polyester blend with specific denier ranges) that can effectively absorb and release multiple types of antiseptic solutions, not limited to CHG. The fiber structure provides general-purpose functionality that works across different antiseptic formulations.
Solution Approach 2:
The invention specifies fiber denier parameters (majority fibers: 0.5-2.0 denier, minority fibers: 2.0-5.0 denier) that create optimal absorption and release characteristics for various antiseptic molecules. By controlling fiber size distribution, the washcloth adapts its performance to different antiseptic solution properties.
2Adaptability or versatility
If CHG is used in the antiseptic solution, then compatibility with existing washcloths is maintained, but antiseptic potency is reduced
Solution Approach 1:
The invention transitions from CHG to more potent antiseptics by changing the chemical composition parameters of the solution while maintaining the physical parameters of the washcloth (fiber denier distribution, weight ratios). This allows the same washcloth structure to deliver superior antiseptic agents.
Solution Approach 2:
The antiseptic solution is formulated as a composite containing the active antiseptic ingredient combined with auxiliary components that enhance stability, absorption, and release characteristics. This composite formulation works effectively with the polyester fiber matrix.
3Reliability
If heat sterilization is applied to the wipe, then antimicrobial efficacy is maintained, but potential degradation of antiseptic solution occurs
Solution Approach 1:
The antiseptic solution is pre-formulated with stabilizers and protective agents before sterilization that prevent degradation during the heat treatment process. This preliminary protection ensures the active ingredient remains effective after autoclaving or other heat-based sterilization methods.
Solution Approach 2:
The formulation includes buffer systems and protective excipients that cushion the antiseptic active ingredient against thermal stress during sterilization. These components absorb the harmful effects of heat, preventing decomposition of the potent antiseptic molecules.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a potent antimicrobial effect with a bis-(dihydropyridinyl)-decane derivative, ensuring effective release and stability of the antiseptic agent on skin, while maintaining purity and antimicrobial efficacy post-sterilization.
Implementation Method 1
an antiseptic solution comprising a bis-(dihydropyridinyl)-decane derivative
Implementation Method 2
The wipe may be sterilized by expositing the package containing the wipe to a temperature of about 110 to 130° C. for at time of about 15 to 30 minutes
Implementation Method 3
The warming mechanism may comprise reactants that create an exothermic reaction when exposed to ambient air or when exposed to each other
Data Source
AI summary
A nonwoven wipe comprises an antiseptic solution comprising a bis-(dihydropyridinyl)-decane derivative, a first fiber having a denier of about 1.5 to about 2.0, and a second fiber having a denier of about 3.0 to 3.5. About 30 wt % to 70 wt % of the total weight of the nonwoven wipe is the first fiber and about 30 wt % to 70 wt % of the total weight of the nonwoven wipe is the second fiber. The bis-(dihydropyridinyl)-decane may be octenidine dihydrochloride.