NRF2 Modulators Regulate Follicle Maturation
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Solution Overview
Problem
Current methods fail to effectively regulate follicle maturation, particularly the primordial to primary transition, leading to challenges in treating infertility and ovulation disorders, and there is a need to control early stages of egg development to prevent premature depletion of egg cells.
Innovation Solution
The use of NRF2 modulators, such as trigonelline, to treat primordial follicles in vitro and promote their maturation, allowing for re-insertion into females to stimulate ovulation and subsequent in vitro fertilization, thereby addressing infertility and ovulation disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used to treat infertility and ovulation disorders, then treatment options are limited, but the effectiveness of regulating follicle maturation is insufficient
Solution Approach 1:
The patent employs parameter changes by modulating the NRF2 pathway through specific compounds (such as trigonelline and PFKFB3 inhibitors) to regulate follicle maturation. This chemical parameter modification enables effective control of the primordial-to-primary follicle transition, directly addressing the insufficiency of conventional treatment methods while providing new therapeutic options for infertility and ovulation disorders
2Duration of action of stationary object
If early stages of egg development are not controlled, then follicle maturation proceeds naturally, but premature depletion of egg cells occurs
Solution Approach 1:
The patent applies preliminary action by intervening at the earliest stage of follicle development (primordial-to-primary transition) to prevent premature depletion of the egg pool. By using NRF2 modulators to control this critical early transition, the invention preserves fertility before depletion occurs, rather than attempting to address the problem after damage has been done
Data Source
AI summary
Compounds and methods for treating infertility or reduced fertility in a female individual are provided, wherein a method includes taking primordial follicles from said individual, treating said follicles in vitro with an NRF2 modulator and re-inserting the treated follicles into said individual. An in vitro method of regulating primordial follicle maturation is provided, wherein the method includes contacting primordial follicles and an NRF2 modulator.