Nucleic Acid Pattern Replication for High-Resolution 2-D Materials

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Solution Overview

Problem

Existing contact-based patterning technologies are limited in their ability to pattern multiple materials in a single process, require multiple molds for different patterns, are restricted to hard surfaces, and have resolution limitations, especially when dealing with curved or soft substrates.

Innovation Solution

A method utilizing nucleic acid-mediated pattern replication, where complementary nucleic acid strands are used to transfer patterns from a first material to a second material, allowing for multi-patterning, selective replication, and high-resolution patterning on various substrates, including soft materials, through a single process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If contact-based patterning technologies (nanoimprint lithography, dip-pen nanolithography, microcontact printing) are used to pattern multiple materials, then manufacturing precision is improved, but device complexity and manufacturing time increase because multiple processes and molds are required

Engineering Contradiction:
Improvepatterning precisionVSAvoidprocess complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent combines multiple patterning functions into a single mold by integrating different pattern regions (e.g., first pattern region with pitch L1, second pattern region with pitch L2) into one unified mold structure. This allows simultaneous formation of multiple different patterns in a single contact-based patterning process, eliminating the need for separate molds and repeated processes while maintaining high patterning precision

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The mold is designed with multi-functionality to perform different patterning tasks simultaneously. Different regions of the same mold can pattern different materials with different pitch requirements in one operation, making the single mold universal for multiple patterning needs rather than requiring specialized molds for each pattern type

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Manufacturing precision

If contact-based patterning technologies are used to achieve high-resolution patterning, then manufacturing precision is improved, but adaptability worsens because these technologies are restricted to hard surfaces and cannot be applied to curved or soft substrates

Engineering Contradiction:
Improvepatterning resolutionVSAvoidsubstrate compatibility
Core Design Contradiction:
Manufacturing precisionVSAdaptability or versatility

Solution Approach 1:

The patent changes the physical parameters of the mold by making it flexible rather than rigid. The flexible mold can deform to conform to curved or soft substrates while still maintaining sufficient mechanical integrity to transfer patterns with high resolution, thus adapting contact-based patterning to previously incompatible substrate types

Inventive Principle:
Principle #35Parameter changes

3Manufacturing precision

If multiple molds are manufactured to form several different patterns, then manufacturing precision is improved, but loss of time and manufacturing cost increase because each pattern requires a separate mold

Engineering Contradiction:
Improvepattern formation precisionVSAvoidmanufacturing time
Core Design Contradiction:
Manufacturing precisionVSLoss of time

Solution Approach 1:

The patent merges multiple pattern-forming capabilities into a single mold structure with different pattern regions. This consolidation allows all patterns to be formed in one contact-based patterning operation rather than requiring sequential use of multiple separate molds, significantly reducing manufacturing time and the number of process steps

Inventive Principle:
Principle #5Merging (Combining)

4Ease of manufacture

If the resolution of the original pattern is used as the limit, then ease of manufacture is improved, but manufacturing precision worsens because the resolution is limited by the original pattern and process resolution

Engineering Contradiction:
Improvepattern replication simplicityVSAvoidpattern resolution
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent introduces a temporal dimension to the patterning process by implementing a two-step method: first forming an initial pattern, then using that pattern as a template for a second contact-based patterning operation. This sequential approach in time allows the final pattern resolution to be determined by the second patterning process rather than being limited by the original pattern resolution

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables simultaneous replication of multiple patterns without repeated processes, allows for high-resolution patterning beyond optical diffraction limits, and supports patterning on diverse materials including soft substrates, reducing time and cost.

Implementation Method 1

bonding the first nucleic acid and a second nucleic acid on the second material through the linker-nucleic acid

Methodology Applied
Scientific EffectComplementary base pairing: Chemical Bonding

Data Source

PatentUS12497646B2Nucleic acid-mediated pattern replication and method of manufacturing 2-D material using the same
Publication Date: 2025.12.16 KOREA ADVANCED INST OF SCI & TECH
  • US12497646B2 patent drawing
  • US12497646B2 patent drawing
  • US12497646B2 patent drawing

AI summary

Provided are the nucleic acid-mediated pattern replication and a method of manufacturing a 2-D material using the same. A method of manufacturing a 2-D material according to an embodiment may include preparing a first material having a first nucleic acid patterned on a surface thereof, bonding a linker-nucleic acid to the first nucleic acid, bonding the first nucleic acid and a second nucleic acid attached to a surface of a second material through the linker-nucleic acid and replicating a pattern of the first material to the surface of the second material, separating the first material, and applying a third material on a pattern replicated to the surface of the second material.