Irreversible Nucleotide Adsorption on Metal-Organic Frameworks
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current metal-organic frameworks (MOFs) lack the ability to irreversibly adsorb nucleotides such as adenosine triphosphate (ATP) and other nucleotides, which could introduce chiral recognition capabilities and enhance catalytic properties, and there is a need for a method to create enantioselective heterogeneous catalysts using these molecules.
Innovation Solution
A method involving the irreversible adsorption of organophosphates and nucleotides onto parent MOFs through aqueous solutions, followed by washing to remove non-adsorbed molecules, resulting in modified MOFs that retain crystallinity and porosity, and can be used as catalysts for enantioselective reactions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If nucleotides are adsorbed onto MOFs to introduce chiral recognition capabilities, then enantioselectivity is improved, but the MOF structure may lose crystallinity
Solution Approach 1:
The patent utilizes the porous structure of MOFs to adsorb nucleotides within the pores while maintaining the overall crystalline framework. The controlled pore environment allows nucleotide incorporation without collapsing the MOF structure, resolving the contradiction between introducing chiral functionality and preserving crystallinity
Solution Approach 2:
The nucleotides are adsorbed at specific locations within the MOF pores rather than uniformly throughout the structure. This localized modification introduces chiral recognition capabilities at specific sites while leaving the rest of the MOF crystalline framework intact, thereby maintaining overall structural stability
2Productivity
If organophosphates are adsorbed onto MOFs through aqueous solutions, then catalytic activity is improved, but the adsorption process requires extended time
Solution Approach 1:
The patent optimizes adsorption parameters including temperature, pH, and organophosphate concentration to enhance adsorption kinetics. By adjusting these parameters, the adsorption process achieves high catalytic loading in reduced time, resolving the contradiction between catalytic activity and adsorption time
Solution Approach 2:
The patent performs preliminary optimization of adsorption conditions before conducting the actual adsorption process. This preliminary action establishes optimal parameters that enable rapid and efficient organophosphate uptake, reducing the time required to achieve high catalytic activity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified MOFs exhibit enhanced enantioselectivity and stability, demonstrating potential as a new class of enantioselective heterogeneous catalysts for reactions like Diels-Alder and Michael additions, with improved activity and selectivity compared to homogeneous nucleotide-based catalysts.
Implementation Method 1
contacting at least one parent MOF with an aqueous solution comprising at least one organophosphate for a time and at a temperature necessary to effectuate substantial adsorption of the at least one organophosphate in and/or on the parent MOFs
Implementation Method 2
DNA binding to MOF nanoparticles by coordination bonds between the phosphate groups of the DNA backbone and the metal ions of the MOF
Implementation Method 3
demonstrating potential as a new class of enantioselective heterogeneous catalysts for reactions like Diels-Alder and Michael additions, with improved activity and selectivity
Data Source
AI summary
Disclosed is a method to modify metal-organic frameworks (MOFs) by irreversible adsorption of nucleotides including, but not limited to, adenosine triphosphate (ATP), guanosine triphosphate (GTP), deoxyadenosine triphosphate (dATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP), the modified MOFs, and the use of the modified MOFs as adsorbents and catalysts.