Nutraceutical Co-crystals for Solubility and Bioavailability
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Solution Overview
Problem
Current nutraceutical formulations face challenges with solubility, stability, and bioavailability, particularly in oral forms, leading to inconsistent therapeutic effects and difficulties in modulating the onset and duration of action.
Innovation Solution
Development of nutraceutical co-crystals formed by hydrogen bonding between specific nutraceuticals and co-crystal formers, such as flavonoids and xanthines, which enhance solubility, stability, and bioavailability, allowing for tailored therapeutic effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nutraceuticals are formulated in conventional forms, then manufacturing is simple, but solubility and bioavailability are poor
Solution Approach 1:
The patent applies composite materials by forming co-crystals that combine nutraceutical compounds with co-crystal formers (such as amino acids, sugars, or other pharmaceutical excipients). This creates a new composite crystalline structure that maintains the therapeutic benefits of the original nutraceutical while significantly improving its solubility and bioavailability characteristics.
Solution Approach 2:
The patent utilizes parameter changes by modifying the physical and chemical parameters of nutraceuticals through co-crystal formation. By changing the crystalline structure and molecular arrangement through co-crystallization with different formers, the patent achieves improved dissolution rates, solubility, and bioavailability without altering the core therapeutic molecule.
2Reliability
If nutraceuticals are administered in standard formulations, then dosing is straightforward, but therapeutic effects are inconsistent
Solution Approach 1:
The patent employs composite materials in the form of co-crystals that provide consistent therapeutic effects. The co-crystal structure ensures uniform distribution and predictable release of the active nutraceutical compound, leading to more reliable and consistent therapeutic outcomes compared to conventional formulations.
Solution Approach 2:
The patent applies hydraulic principles through the use of aqueous solvation and dissolution mechanisms. The co-crystal formulations are designed to optimize their interaction with aqueous biological fluids, ensuring predictable and consistent dissolution rates that lead to reliable therapeutic effects.
3Duration of action of moving object
If conventional nutraceutical forms are used, then onset of action is rapid, but duration of action is short
Solution Approach 1:
The patent applies dynamics by creating formulations with tunable release characteristics. The co-crystal structures can be engineered to provide controlled release profiles, allowing optimization of both onset and duration of action. The dynamic nature of co-crystal formation enables adjustment of release rates to achieve desired therapeutic kinetics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nutraceutical co-crystals demonstrate improved solubility, stability, and bioavailability, enabling more controlled and effective therapeutic profiles, including faster or delayed onset and longer-lasting plasma concentrations.
Implementation Method 1
co-crystals formed by hydrogen bonding between specific nutraceuticals and co-crystal formers
Data Source
AI summary
Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.