Synergistic Nutrient Blend for Cognitive Health in Aging Mammals

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Solution Overview

Problem

Current methods for improving cognitive and emotional health in aging mammals, such as caloric restriction and fasting, are challenging to adhere to and may require high doses of single nutrients with low efficacy, necessitating the development of more effective nutritional solutions that mimic the health benefits of these lifestyle changes without the need for drastic lifestyle modifications.

Innovation Solution

A combination of nutrients like spermidine and ellagic acid, or docosahexaenoic acid (DHA) and curcumin, is used to enhance cognitive function and emotional health, administered in a synergistic blend that activates Transcription Factor EB (TFEB) downstream genes, mimicking the effects of caloric restriction without requiring lifestyle changes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If caloric restriction or fasting regimens are used to improve cognitive and emotional health, then health benefits are achieved, but adherence is difficult and lifestyle changes are required

Engineering Contradiction:

Improvehealth benefitsVSAvoidadherence

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent uses caloric restriction mimetics (CRMs) that copy the health benefits of caloric restriction and fasting without requiring actual lifestyle changes. These mimetics activate similar biological pathways (autophagy, AMPK, SIRT1) that mediate the benefits of restriction diets, allowing animals to receive cognitive and emotional health benefits without adhering to restrictive eating protocols

Inventive Principle:

Principle #26Copying

Solution Approach 2:

The patent introduces intermediary substances (nutritional compositions containing CRMs) that mediate between the desired health outcomes and the difficulty of lifestyle change. These compositions serve as a bridge, providing the biological effects of caloric restriction through administered nutrients rather than requiring direct dietary restriction

Inventive Principle:

Principle #24Intermediary (Mediator)

2Ease of manufacture

If single nutrient supplementation is used to improve cognitive health, then supplementation is simple, but high doses are required with low efficacy

Engineering Contradiction:

Improvesupplementation simplicityVSAvoidefficacy

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The patent combines multiple nutrients with complementary mechanisms of action into synergistic nutritional compositions. Examples include combining resveratrol with Pterostilbene, or DHA with curcumin and quercetin. This merging allows lower individual doses while achieving higher overall efficacy through synergistic effects, addressing the limitation of single-nutrient supplementation

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates composite nutritional formulations that integrate multiple active ingredients working together. These composite compositions leverage synergistic interactions between nutrients to enhance cognitive and emotional health effects more effectively than single nutrients, achieving better efficacy at lower doses

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS20250009687A1Compositions and methods using a combination of nutrients to support cognition and emotional health in a mammal

Publication Date: 2025.01.09 SOCIETE DES PRODUITS NESTLE SA

AI summary

Compositions and methods can use at least one of (a) a combination of spermidine and ellagic acid or (b) a combination of docosahexaenoic acid (DHA) and curcumin to enhance cognition and emotional health in a mammal. The mammal is preferably an ageing or elderly human or an ageing or elderly companion animal, preferably an elderly dog.