Nutritional Composition for Cancer Therapy Side Effect Mitigation

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Solution Overview

Problem

Cancer therapies such as chemotherapy, radiation, and target therapies often cause severe side effects due to their impact on the human immune system, leading to complications like weight loss and hair loss, and can be detrimental to patients' health.

Innovation Solution

A nutritional composition comprising specific nutrients like selenium yeast, fish oil, beta carotene, resveratrol, vitamins, and minerals that, when taken orally, work synergistically to enhance the immune system and support anti-tumor activity, reducing the harsh effects of cancer therapies and aiding in cancer treatment and prevention.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If cancer therapies (chemotherapy, radiation, target therapies) are administered to treat cancer, then anti-tumor activity is improved, but immune system function deteriorates causing severe side effects

Engineering Contradiction:
Improveanti-tumor activityVSAvoidimmune system damage
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies this principle by using antioxidants (vitamins C, E, beta-carotene, selenium) to convert the harmful oxidative stress caused by cancer therapies into a beneficial effect. These antioxidants neutralize free radicals generated during therapy, protecting immune cells from damage while allowing the anti-tumor activity to proceed. This transforms the harmful oxidative byproducts of therapy into an opportunity for enhanced immune protection.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent introduces nutritional supplements as intermediary substances that mediate between the cancer therapy and the immune system. These supplements (amino acids, vitamins, minerals, fatty acids) act as protective intermediaries that absorb the harmful impact of therapy on immune cells while maintaining the therapeutic anti-tumor effect. The intermediaries bridge the gap between necessary aggressive therapy and immune system preservation.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If high doses of cancer therapy are used to increase anti-tumor efficacy, then cancer treatment effectiveness is improved, but patient health deteriorates due to severe side effects

Engineering Contradiction:
Improvecancer treatment effectivenessVSAvoidtherapy-induced side effects
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent implements prior cushioning by administering antioxidants and immune-supporting nutrients before and during cancer therapy. These supplements pre-condition the immune system and create a protective buffer against the harsh effects of high-dose therapy. For example, vitamins C and E are given beforehand to build up antioxidant reserves, cushioning the immune system against the oxidative burst that occurs during chemotherapy and radiation.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

Solution Approach 2:

The patent creates a composite nutritional formulation combining multiple substances (amino acids, vitamins, minerals, fatty acids, antioxidants) that work synergistically to protect patient health during high-dose therapy. This composite nutritional approach provides multi-faceted protection: amino acids support protein synthesis for immune cell repair, fatty acids maintain cell membrane integrity, vitamins provide antioxidant protection, and minerals support enzymatic functions. Together, they form a comprehensive protective matrix that enables higher therapeutic doses.

Inventive Principle:
Principle #40Composite materials

3Reliability

If cancer therapy is administered to eliminate neoplastic growth, then tumor control is improved, but weight loss and hair loss occur due to immune system taxation

Engineering Contradiction:
Improvetumor controlVSAvoidbody mass and hair
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The patent enables self-service by providing the immune system and body with necessary nutritional building blocks that allow it to repair and maintain itself during therapy. Amino acids serve as raw materials for protein synthesis and immune cell production, enabling the body to regenerate lost tissue. B vitamins support metabolic processes that maintain energy levels and prevent cachexia. This self-service approach allows the body to sustain itself through the stress of therapy without excessive weight loss.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent changes the nutritional parameter landscape by introducing specific nutrients that alter the body's metabolic state during therapy. Omega-3 fatty acids change membrane fluidity and reduce inflammatory markers, protecting against tissue damage. Antioxidants change the oxidative-reductive balance, protecting cells from therapy-induced damage. These parameter changes in nutritional status create a more resilient physiological state that resists the catabolic effects of therapy that lead to weight and hair loss.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS20240350569A1Nutritional Composition
Publication Date: 2024.10.24 HSIA HOUN SIMON

AI summary

The present invention provides nutritional compositions that are employed as oral supplementation to the human diet and methods for using such nutritional compositions. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer.