Oat Extract Composition With Balanced Avenanthramide and β-Glucan
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Solution Overview
Problem
Existing extraction processes for oat extracts rich in avenanthramides and β-glucans typically result in separate fractions due to their different solubility properties, limiting the combined beneficial biological activities of both compounds.
Innovation Solution
A specific extraction process followed by an adsorption-desorption step using a suitable adsorber resin to enrich both avenanthramides and β-glucans simultaneously, achieving a balanced ratio of 1:4 to 4:1 and low salt content ≤1.0 wt %.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional extraction processes are used to obtain avenanthramides and β-glucans, then one compound class can be extracted, but the other is lost in separate fractions due to different solubility properties
Solution Approach 1:
The patent uses a two-stage extraction process with different solvents as intermediaries: first water to extract β-glucans, then ethanol to extract avenanthramides from the remaining material. This intermediary approach allows both compound classes to be obtained in separate steps that can be combined, resolving the solubility conflict without requiring a single complex extraction system
Solution Approach 2:
The extraction process is divided into two separate stages: Stage 1 extracts β-glucans using water, and Stage 2 extracts avenanthramides using ethanol. This segmentation allows each extraction to be optimized for its target compound while the overall process delivers both compounds in the final composition
2Quantity of substance
If extraction processes target high concentrations of avenanthramides, then avenanthramide content increases, but β-glucan content decreases and vice versa
Solution Approach 1:
The patent systematically varies extraction parameters including solvent composition (water vs. ethanol), temperature (40-60°C), and extraction time to optimize the yield and ratio of both compound classes. By changing these parameters across two stages, the process achieves precise control over the final avenanthramide to β-glucan ratio while maintaining high concentrations of both
3Quantity of substance
If multiple extraction steps are used to obtain both avenanthramides and β-glucans, then both compounds are obtained, but the process becomes more complex and time-consuming
Solution Approach 1:
The two-stage extraction process is designed to be continuous rather than batch-separated: the aqueous extract from Stage 1 is processed while the solid residue immediately undergoes Stage 2 extraction. This continuous workflow minimizes idle time and allows both extractions to overlap in the overall process timeline, reducing total time despite the dual-stage nature
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting oat extract exhibits enhanced biological activities, including antioxidant and anti-inflammatory effects, suitable for dermatological, cosmetic, and pharmaceutical applications, while maintaining stability and ease of use.
Implementation Method 1
an adsorption step followed by an elution step from the adsorber
Implementation Method 2
an elution step from the adsorber with an appropriate solvent
Data Source
AI summary
The present invention relates generally to a composition or an oat extract comprising at least one avenanthramide compound or an analogue thereof and at least one β-glucan compound at predetermined ratios and having a low salt content. In addition, the present invention relates to a method for preparing such an oat extract, an oat extract obtained by said method, and the use of said composition or oat extract for the preparation of foods, food supplements, cosmetic, pharmaceutical or veterinary preparations. Finally, the present invention relates to foods, food supplements, cosmetics, pharmaceuticals or veterinary preparations comprising said composition or oat extract.