Obese Patient Parenteral Nutrition Solution

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Conventional parenteral nutrition solutions are not tailored to the specific nutritional needs of obese intensive care patients, leading to increased complications, metabolic issues, and mortality due to inadequate macronutrient ratios and amounts, as well as difficulties in administration and dosage.

Innovation Solution

A parenteral nutrition solution comprising 500-834 mL of an amino acid solution (50-83 g of amino acids), 167-278 mL of a glucose solution (67-111 g of glucose), and 83-139 mL of a lipid emulsion (17-28 g of lipids) per 1000 mL, with specific components and ratios designed to meet the unique needs of obese patients, including electrolytes and vitamins, and administered via a three-chamber bag for ease and accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional parenteral nutrition solutions are used for obese intensive care patients, then the solutions are designed for normal-weight or underweight patients, but the nutritional needs of obese patients are not met leading to increased complications

Engineering Contradiction:

Improvenutritional adequacyVSAvoidadaptability to obese patients

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies local quality by creating a parenteral nutrition solution with a specifically tailored macronutrient composition for obese patients, differing from conventional solutions. The solution contains adjusted ratios of amino acids (1.2-2.0 g/kg ideal body weight), carbohydrates (2.0-4.0 g/kg ideal body weight), and lipids (0.8-1.5 g/kg ideal body weight), along with modified micronutrient levels, to address the unique metabolic requirements of obese intensive care patients

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent implements parameter changes by modifying the concentration and ratio of macronutrients and micronutrients in the parenteral nutrition solution. Key parameters include reducing glucose concentration to 5-10% (lower than conventional solutions), adjusting amino acid concentrations to 0.5-1.0 g/100 mL, and modifying lipid emulsion types and concentrations to match the reduced metabolic demands of obese patients while preventing refeeding syndrome

Inventive Principle:

Principle #35Parameter changes

2Ease of operation

If parenteral nutrition is administered based on actual body weight, then dosage is simplified, but massive oversupply of macronutrients occurs

Engineering Contradiction:

Improvedosage calculation simplicityVSAvoidmacronutrient supply amount

Core Design Contradiction:

Ease of operationVSQuantity of substance

Solution Approach 1:

The patent applies preliminary action by pre-calculating and formulating the parenteral nutrition solution with macronutrient amounts based on ideal body weight rather than actual body weight. The solution is designed with predetermined concentrations that account for the obese patient's ideal body weight, eliminating the need for complex dosage calculations during administration and preventing oversupply

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent uses partial action by administering nutrition based on ideal body weight (a partial measure) rather than actual body weight. This approach provides sufficient nutrition for the patient's metabolic needs while avoiding the excessive macronutrient supply that would result from dosing based on total body weight including excess adipose tissue

Inventive Principle:

Principle #16Partial or excessive action

3Reliability

If individual solutions for amino acids, carbohydrates, and lipids are administered separately, then nutritional needs can be precisely met, but administration complexity and time expenditure increase

Engineering Contradiction:

Improvenutritional precisionVSAvoidadministration system complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies merging by combining amino acids, carbohydrates, and lipids into a single integrated parenteral nutrition solution. This all-in-one formulation maintains the precise macronutrient ratios needed for obese patients while simplifying administration to a single container, reducing nursing time, and minimizing the risk of dosing errors associated with multiple separate solutions

Inventive Principle:

Principle #5Merging (Combining)

4Reliability

If parenteral nutrition solutions are tailored to obese patients' needs, then complications are reduced, but solution formulation complexity increases

Engineering Contradiction:

Improvecomplication reductionVSAvoidsolution formulation simplicity

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent implements parameter changes by establishing specific concentration ranges for macronutrients (amino acids: 0.5-1.0 g/100 mL, carbohydrates: 5-10%, lipids: adjusted to patient needs) and micronutrients (vitamins and trace elements at modified levels). These standardized parameter ranges simplify the manufacturing process while ensuring the solution meets the unique nutritional requirements of obese patients and reduces complications

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentEP2734217B1Product for parenteral feeding of obese intensive care patients

Publication Date: 2020.12.02 FRESENIUS KABI DEUTSCHLAND GMBH

AI summary

The present invention relates to an amino-acid-rich, low-lipid-content and low-carbohydrate-content parenteral nutrition solution for administration to obese intensive-care patients, and also to a three-chamber bag which comprises, separately from one another, in three different chambers, the amino acid component, the carbohydrate component and the lipid component of the parenteral nutrition solution.