Occult Blood Detection Composition with Fast Color Change
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Solution Overview
Problem
Existing occult blood detection methods lack high sensitivity and ease of detection, making early screening for urinary and digestive diseases inefficient.
Innovation Solution
A composition comprising specific ratios of organic solvent, thickener, benzidine, peroxide, EDTA-2Na, and water, which enables fast color change, long color retention, and high sensitivity for detecting occult blood in excretion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional occult blood detection methods are used, then detection can be performed, but sensitivity is insufficient and early screening efficiency is low
Solution Approach 1:
The patent optimizes the concentration ratios of key components in the detection composition: benzidine (0.01-2 parts by weight), peroxide (0.01-5 parts by weight), EDTA-2Na (0.001-0.5 parts by weight), organic solvent (20-80 parts by weight), and thickener (0.01-50 parts by weight). These parameter adjustments enhance the reaction sensitivity and color change intensity, enabling detection of occult blood at lower concentrations while maintaining high screening efficiency
Solution Approach 2:
The patent creates a composite detection system combining multiple components: benzidine as the chromogenic substrate, peroxide as the oxidizing agent, EDTA-2Na as the chelating agent to stabilize the reaction environment, organic solvent to dissolve reagents, and thickener to control viscosity. This composite formulation synergistically improves both detection sensitivity and operational efficiency for early disease screening
2Ease of operation
If detection composition is simplified for ease of use, then operation becomes easier, but color change speed and retention duration are reduced
Solution Approach 1:
The patent pre-mixes all detection reagents (benzidine, peroxide, EDTA-2Na, organic solvent, and thickener) into a single ready-to-use composition. This preliminary preparation eliminates the need for users to separately prepare and mix multiple reagents during operation, maintaining ease of use while ensuring the optimized component ratios deliver fast color change and long-lasting results
3Measurement precision
If benzidine and peroxide concentrations are increased to improve sensitivity, then detection sensitivity increases, but color retention duration decreases
Solution Approach 1:
The patent carefully balances the concentration parameters of benzidine (0.01-2 parts by weight) and peroxide (0.01-5 parts by weight) within specific ranges, rather than simply maximizing them. This optimized parameter selection, combined with adding EDTA-2Na (0.001-0.5 parts by weight) to stabilize the reaction environment and incorporating thickener (0.01-50 parts by weight) to control reaction kinetics, achieves both high detection sensitivity and extended color retention duration
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively detects occult blood with a fast color change speed, long color retention duration, and high sensitivity, facilitating rapid and accurate early screening for urinary and digestive diseases.
Implementation Method 1
0.01-2 parts by weight of benzidine, 0.01-5 parts by weight of peroxide
Implementation Method 2
fast color change speed, long color retention duration
Implementation Method 3
0.001-0.5 parts by weight of EDTA-2Na
Implementation Method 4
20-80 parts by weight of an organic solvent
Implementation Method 5
0.01-50 parts by weight of a thickener
Data Source
AI summary
Provided in the present application are a composition for detecting occult blood in excreta, and a preparation method therefor and the use thereof. The composition comprises, in parts by weight, 20-80 parts of organic solvent, 0.01-50 parts of thickener, 0.01-2 parts of benzidine, 0.01-5 parts of peroxide, 0.001-0.5 parts of EDTA-2Na and 10-80 parts of water. The composition provided in the present application can quickly and effectively detect the occult blood condition of excreta, has fast color change, long color retention time and high sensitivity.