Occult Blood Test Kit With Fracture-Activated Peroxide Packet
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Solution Overview
Problem
Existing methods for detecting occult blood in feces, such as those using guaiac resin materials, are unable to reliably detect minute amounts of blood present in intestinal cancer or other disorders, as the blood is undetectable to the naked eye and requires improvement for accurate detection.
Innovation Solution
A kit comprising a sealed waterproof package with an activated absorbent sheet impregnated with guaiac material and a sealed friable packet containing a developing solution, where the packet is manually compressed to release hydrogen peroxide solution, which is absorbed by the sheet, allowing for the detection of occult blood by color change upon contact with feces, with an optional HEMI test solution for confirmation of reactivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If guaiac resin material is used to detect occult blood, then the test can identify blood presence through color change, but the detection precision is insufficient for minute amounts of blood
Solution Approach 1:
The patent changes the chemical parameters of the developing solution by specifying precise concentrations (e.g., hydrogen peroxide at 3%, glacial acetic acid at 10%) and using activated absorbent material with controlled porosity. These parameter optimizations enhance the sensitivity of the guaiac reaction, enabling reliable detection of minute blood amounts while maintaining test reliability through consistent chemical conditions.
Solution Approach 2:
The patent employs composite material structure by combining activated absorbent material (such as activated cellulose or activated charcoal) with guaiac resin. This composite approach enhances both the precision and reliability of detection by improving blood concentration at the reaction site while maintaining stable chemical properties for consistent test results.
2Ease of operation
If the developing solution is pre-mixed with the guaiac sheet, then the test is simpler to perform, but the shelf life and stability of the kit are reduced
Solution Approach 1:
The patent divides the testing system into separate functional segments: the guaiac-impregnated absorbent sheet and the developing solution in a sealed packet. This segmentation allows each component to be optimized independently for stability and shelf life, while the simple activation process (breaking the packet and mixing) maintains ease of operation. The sealed packet prevents premature reaction and maintains reagent stability over extended storage periods.
Solution Approach 2:
The guaiac material is pre-impregnated onto the activated absorbent material during manufacturing, and the developing solution is pre-prepared and sealed in the packet. This preliminary preparation ensures that when the user activates the kit by breaking the packet, the reaction components are immediately available in optimal concentrations, simplifying the user's task while maintaining long-term stability through proper sealing and storage conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively indicates the presence of occult blood through a visible blue color change on the absorbent sheet, providing a reliable and user-friendly means for detecting occult blood in feces, enhancing the accuracy of early disease detection.
Implementation Method 1
This material reacts with a peroxide in the presents of occult blood in feces to produce a blue color
Implementation Method 2
a sheet of an activated absorbent material impregnated with a guaiac material
Implementation Method 3
the solution to be absorbed by the sheet
Data Source
AI summary
A kit and method are used to detect the presence of occult blood in feces. The kit has a closed and sealed package containing a sheet of absorbent material impregnated with a guaiac material and a friable packet holding a hydrogen peroxide solution. The packet is sealed to prevent the solution from escaping the packet until it is manually fracture. With the sheet and the packet both within the closed package and in contact with each other, a user manually compresses the packet to break the packet and release the solution, which is absorbed by the sheet material. The package remains closed for a sufficient time for the solution to be absorbed by the sheet. The user then opens the packaging and removes the sheet that is now wetted with the solution, using the sheet in the conventional manner to collect a feces sample. A blue color appearing on the sheet indicates the presence of occult blood in the feces sample.