Ocular Implant Needle Retention Plug for Controlled Ejection
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Solution Overview
Problem
Existing intraocular implant delivery systems face challenges with secure retention of implants within the delivery device, leading to potential damage or premature release, and lack safe, controlled, and minimally-invasive administration methods.
Innovation Solution
A delivery device with a retention plug formed from a flowable hydroxypropyl methylcellulose (HPMC) solution and a shortened push rod, which slows ejection speed and prevents inadvertent release, ensuring safe and controlled implant deployment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a hard plug is used to secure an ocular implant within the needle, then the implant retention is improved, but the implant may be damaged or the needle may be weakened
Solution Approach 1:
The patent changes the physical state and material properties of the retention mechanism from a hard solid plug to a flowable gel composition. This gel has sufficient viscosity to maintain implant retention during handling, yet is soft and compliant enough to avoid damaging the implant or weakening the needle. The gel's flowable nature allows it to conform to the needle lumen shape and apply uniform retention force without concentrated stress points.
Solution Approach 2:
The flowable gel composition acts as an intermediary substance between the implant and the needle lumen. Rather than using direct mechanical contact with a hard plug, the gel mediates the retention function by providing a compliant interface that holds the implant securely while protecting both the implant and needle from damage. The gel can be easily removed after implant delivery without leaving debris or requiring complex removal mechanisms.
2Productivity
If the push rod is made longer to ensure complete implant ejection, then the ejection completeness is improved, but the ejection speed increases causing potential retinal injury
Solution Approach 1:
The patent modifies the push rod length parameter to an optimized value that balances ejection completeness with safety. The push rod is made sufficiently long to ensure complete implant ejection from the needle lumen, but not so long as to create excessive travel distance that would result in dangerous ejection speeds. This optimized length allows the implant to be fully expelled while controlling the velocity to prevent retinal injury.
Solution Approach 2:
The patent applies a partial action approach by using a push rod length that is sufficient for complete ejection but not excessively long. The push rod provides just enough force and travel to expel the implant completely from the needle, avoiding both incomplete ejection and the hazards of excessive ejection speed. This optimized partial action achieves the minimum necessary effect for safety while avoiding over-action.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides reliable, safe, and controlled implant delivery with reduced risk of retinal injury and ocular contamination, enhancing the safety and reliability of intraocular implant administration.
Implementation Method 1
a retention plug formed from a flowable hydroxypropyl methylcellulose (HPMC) solution... having a concentration that is greater than 2.5% w:w and less than about 4% w:w
Data Source
Figure 1A~1C
Figure 1D
Figure 1E
AI summary
A system for treating an eye of a patient in need including a delivery device having a housing sized to be held by an operator, an actuator and a distal nose cone; a needle coupled to and extending distal from the nose cone, the needle having a lumen and a beveled distal end defining a distal opening having a sharpened tip and heel proximal the distal opening; and a retention plug positioned within and spanning the lumen of the needle proximal to the heel; and an intraocular implant positioned within the lumen of the needle proximal to the retention plug. The retention plug is formed from a flowable retainer solution of hydroxypropyl methylcellulose (HPMC) in water having a concentration that is greater than 2.5% w:w and less than about 4% w:w. Related devices and methods are provided.