Odontoblast-Promoting Calcium Agent for Dentin Bridge Formation

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing dental treatments that reach the dental pulp often cause weakening of the tooth structure and can lead to atrophy of the dental pulp due to the removal of infected portions, as conventional methods fail to effectively promote odontoblast proliferation and differentiation.

Innovation Solution

An odontoblast proliferation/differentiation promoting agent containing a calcium salt of 4-(meth)acryloyloxyethyltrimellitic acid, optionally with a bioabsorbable material and an anti-inflammatory agent, is used to stimulate odontoblasts and stem cells to form dentin, filling the space left by removed infected portions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If infected portion of dental pulp is removed, then dental caries is treated, but tooth structure is weakened and dental pulp atrophies

Engineering Contradiction:

Improvecaries treatment effectivenessVSAvoidtooth structure strength

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The patent applies preliminary action by introducing a pulp capping agent containing calcium salt of 4-(meth)acryloyloxyethyltrimellitic acid before the infected pulp is completely removed. This agent is placed in the pulp cavity to stimulate odontoblast proliferation and dentin bridge formation, creating a protective barrier that prevents subsequent pulp atrophy and maintains tooth structure strength.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent uses an intermediary substance - the pulp capping agent containing calcium salt of 4-(meth)acryloyloxyethyltrimellitic acid - that mediates between the removed infected pulp and the remaining healthy pulp. This intermediary stimulates odontoblasts to proliferate and form dentin bridges, preventing direct contact between bacteria and healthy pulp while maintaining structural integrity.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If conventional pulp capping agent is used, then odontoblasts are stimulated to form dentin bridge, but dental pulp volume is reduced causing atrophy

Engineering Contradiction:

Improvedentin bridge formationVSAvoiddental pulp volume

Core Design Contradiction:

ReliabilityVSVolume of stationary object

Solution Approach 1:

The patent applies parameter changes by modifying the chemical composition of the pulp capping agent to include calcium salt of 4-(meth)acryloyloxyethyltrimellitic acid. This specific chemical parameter change stimulates not only dentin bridge formation but also odontoblast proliferation and differentiation, thereby increasing or maintaining pulp volume rather than reducing it, preventing atrophy.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses a composite approach by combining calcium salt of 4-(meth)acryloyloxyethyltrimellitic acid with other beneficial components in the pulp capping agent. This composite formulation simultaneously promotes dentin bridge formation, odontoblast proliferation, and pulp tissue maintenance, achieving multiple functions that prevent volume reduction and atrophy.

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS20250295625A1Agent for promoting odontoblast propagation and differentiation

Publication Date: 2025.09.25 SUN MEDICAL CO LTD

AI summary

An odontoblast proliferation/differentiation promoting agent contains a calcium salt of 4-(meth)acryloyloxyethyltrimellitic acid.