Offset Actuator Drug Delivery Device for Gastrointestinal Attachment
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Solution Overview
Problem
Current drug delivery devices face challenges in delivering low permeable and low water soluble active drug substances orally due to stability issues and limited absorption in the gastrointestinal tract, primarily due to the gastrointestinal wall barrier and pre-systemic metabolism.
Innovation Solution
A drug delivery device with a central axis and offset actuator mechanism, featuring rotating body parts and attachment parts that can attach to the gastrointestinal wall, ensuring stability and enhanced absorption by rotating to improve attachment and penetration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If oral administration is used to deliver low permeable and low water soluble active drug substances, then patient acceptance is improved, but stability and absorption are worsened due to gastrointestinal wall barrier and pre-systemic metabolism
Solution Approach 1:
The device is divided into multiple body parts (first body part, second body part) that can rotate relative to each other, allowing the attachment parts to be positioned at different locations and orientations on the gastrointestinal wall, thereby improving both patient acceptance and drug delivery reliability
Solution Approach 2:
The actuator mechanism enables dynamic rotation of body parts to adjust the positioning and orientation of attachment parts, allowing the device to adapt to different gastrointestinal wall positions and optimize drug absorption while maintaining stability
2Length of moving object
If the actuator mechanism is located towards the first longitudinal end, then the first attachment part can be positioned closer to the second attachment part, but the device complexity increases
Solution Approach 1:
The actuator mechanism is asymmetrically positioned towards the first longitudinal end rather than being centrally located, which allows the first attachment part to be closer to the second attachment part while managing the complexity through strategic placement of mechanical components
Data Source
AI summary
A drug delivery device comprising a central axis extending from a first longitudinal end of the drug delivery device to a second longitudinal end of the drug delivery device, a first body part, a second body part, an attachment part connected to the first body part, and an actuator mechanism configured to rotate one of the first body part and/or the second body part, wherein the actuator mechanism is located more towards the first longitudinal end than the second longitudinal end along the central axis.