Oil-in-Water Emulsion Stability with High-Pressure Particle Reduction
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Solution Overview
Problem
Oil-in-water emulsified compositions destabilize when electrolyte salt-type drugs are added, particularly in low-viscosity compositions, making it difficult to maintain stability over time and varying temperatures.
Innovation Solution
An oil-in-water emulsified composition is created using high pressure emulsification to miniaturize particles, incorporating potassium 4-methoxysalicylate as the salt-type drug, POE alkyl ether surfactant, N-long chain acyl acidic amino acid mono salt, higher fatty acid soaps, and specific oil components, which maintains stability even with high electrolyte concentrations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If electrolyte salt-type drugs are added to oil-in-water emulsified compositions, then the desired high functions (humectant, whitening, antioxidation actions) are achieved, but the emulsification stability dramatically worsens over time and over varying temperatures
Solution Approach 1:
The patent changes the particle size parameter through high-pressure emulsification, reducing emulsified particles to 0.03-0.15 μm. This parameter change fundamentally alters the emulsion's stability characteristics, allowing it to resist destabilization by electrolytes while maintaining desired functional properties.
Solution Approach 2:
The patent uses a composite emulsion system combining multiple surfactants (higher fatty acid soaps, N-long chain acyl acidic amino acid mono salts, and other surfactants) with specifically controlled particle sizes. This composite approach creates synergistic effects that maintain emulsion stability even in the presence of electrolyte salt-type drugs.
2Ease of operation
If high pressure emulsification is used to miniaturize particles to achieve low viscosity and aqueous solution-like properties, then the cosmetic texture is improved, but the selection range of surfactant and oil component combinations becomes narrow, making stabilization difficult when salt type drugs are blended in
Solution Approach 1:
The patent maintains the beneficial low viscosity and aqueous solution-like properties achieved through high-pressure emulsification while changing the surfactant combination parameters. By using specific combinations of higher fatty acid soaps, N-long chain acyl acidic amino acid mono salts, and other surfactants in controlled ratios, the patent expands the acceptable combination range while preserving the desired cosmetic texture.
Solution Approach 2:
The patent creates a composite surfactant system that combines higher fatty acid soaps, N-long chain acyl acidic amino acid mono salts, and other surfactants in specific ratios. This composite approach provides both the desired low-viscosity cosmetic texture and the stability needed to accommodate electrolyte salt-type drugs, thereby expanding formulation flexibility.
3Stability of the object's composition
If emulsified particle size is reduced to 0.03-0.15 μm through high pressure emulsification, then emulsification stability is improved and electrolyte salt type drugs can be stably blended, but the manufacturing process complexity increases
Solution Approach 1:
The patent employs high-pressure emulsification technology, utilizing hydraulic pressure (50-200 MPa) to force the emulsion through a narrow gap, generating intense shear forces that reduce particle size to 0.03-0.15 μm. This hydraulic approach achieves the desired particle size and stability with a well-established industrial process.
Solution Approach 2:
The high-pressure emulsification process generates intense mechanical vibration and shear forces as the emulsion passes through the narrow gap under high pressure. This mechanical energy input efficiently reduces particle size to the target range while maintaining a relatively simple continuous processing approach.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves superior emulsification stability, allowing for the stable blending of electrolyte salt-type drugs, maintaining a cream-like texture and aqueous solution-like physical properties, even after four weeks at elevated temperatures.
Implementation Method 1
miniaturization of the emulsified particles by means of high pressure emulsification under a pressure of 50 MPa or more down to an emulsified particle range of 0.03-0.15 μm
Implementation Method 2
two or more types of higher fatty acids and alkali that constitutes higher fatty acid soap
Data Source
AI summary
The present invention provides an oil-in-water emulsified composition comprising the following ingredients (A)-(G) characterized by miniaturization of the emulsified particles by means of high pressure emulsification: (A) salt type drug (B) hydrophilic nonionic surfactant (C) N-long chain acyl acidic amino acid mono salt (D) two or more types of higher fatty acids and alkali that constitutes higher fatty acid soap (E) higher alcohol (F) oil component (G) water. The object of the present invention is to provide an oil-in-water emulsified composition prepared by miniaturizing emulsified particles by means of a high pressure emulsification method, said composition being superior in terms of emulsification stability such that electrolyte salt type drugs can be stably blended in.